Polavarapu Prasad L
Department of Chemistry, Vanderbilt University, Nashville, TN 37235, USA.
Molecules. 2016 Aug 12;21(8):1056. doi: 10.3390/molecules21081056.
Chiroptical spectroscopy has emerged as a promising tool for the determination of absolute configurations and predominant conformations of chiral molecules in academic laboratories. This promise has led to the adaption of chiroptical spectroscopic methods as valuable tools in chiral drug discovery research programs of the pharmaceutical industry. Most major pharmaceutical companies have invested in in-house chiroptical spectroscopy applications and reported successful outcomes. In the context of continuously increasing applications of chiroptical spectroscopy for chiral molecular structure determination, a review of recent developments and applications for chiral drugs is presented in this manuscript.
在手性分子结构测定方面，圆二色光谱已成为学术实验室中用于确定手性分子绝对构型和优势构象的一种很有前景的工具。这一前景促使圆二色光谱方法被应用于制药行业手性药物发现研究项目中，成为有价值的工具。大多数大型制药公司都已投资建立内部圆二色光谱应用，并报告了成功的成果。鉴于圆二色光谱在确定手性分子结构方面的应用不断增加，本文对其在手性药物方面的最新进展和应用进行了综述。
