Department of Chemistry, Physical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QZ, UK.
Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford OX1 3PT, UK.
Sci Adv. 2016 Aug 10;2(8):e1600560. doi: 10.1126/sciadv.1600560. eCollection 2016 Aug.
There are no satisfactory methods for monitoring oxygen consumption in critical care. To address this, we adapted laser absorption spectroscopy to provide measurements of O2, CO2, and water vapor within the airway every 10 ms. The analyzer is integrated within a novel respiratory flow meter that is an order of magnitude more precise than other flow meters. Such precision, coupled with the accurate alignment of gas concentrations with respiratory flow, makes possible the determination of O2 consumption by direct integration over time of the product of O2 concentration and flow. The precision is illustrated by integrating the balance gas (N2 plus Ar) flow and showing that this exchange was near zero. Measured O2 consumption changed by <5% between air and O2 breathing. Clinical capability was illustrated by recording O2 consumption during an aortic aneurysm repair. This device now makes easy, accurate, and noninvasive measurement of O2 consumption for intubated patients in critical care possible.
目前尚无令人满意的方法来监测重症监护中的氧耗量。为此，我们采用激光吸收光谱法，每 10 毫秒测量一次气道中的 O2、CO2 和水蒸气。该分析仪集成在一种新型呼吸流量计内，其精度比其他流量计高出一个数量级。如此高的精度，加上气体浓度与呼吸流量的精确对准，使得通过直接对 O2 浓度与流量的乘积进行时间积分来确定 O2 耗量成为可能。通过积分平衡气体（N2 和 Ar）流量并显示这种交换几乎为零，说明了这种精度。在空气和 O2 呼吸之间，测量的 O2 耗量变化<5%。通过记录主动脉瘤修复期间的 O2 消耗，说明了其临床能力。该设备现在可以为重症监护中的插管患者轻松、准确和无创地测量 O2 消耗量。
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