Otunctemur Alper, Dursun Murat, Ozer Kutan, Horsanali Ozan, Ozbek Emin
Department of Urology, Okmeydani, Training and Research Hospital, Istanbul, Turkey.
Department of Urology, Ataturk Training and Research Hospital, Izmir, Turkey.
Int Braz J Urol. 2016 Sep-Oct;42(5):955-959. doi: 10.1590/S1677-5538.IBJU.2015.0396.
The aim of this study was to evaluate the relationship between tumor size and grade with visceral adipose index (VAI) levels in patients with renal cell carcinoma.
We retrospectively reviewed the records of 310 consecutive patients with RCC who underwent radical nephrectomy at our institution between January 2007 and May 2014. VAI was calculates for males and females seperately as this formula like previous study. The relationship between tumor size and nuclear grade with VAI levels were evaluated statisticaly. Analyses were completed using Chi-square tests and Logistic regression analysis.
Among the 310 total patients analyzed in our study, there were 176 males (56.8%) and 134 females (43.2%). VAI levels were statistically higher in men and women with high tumor size (p < 0,001). VAI levels were statistically higher in men and women with high fuhrman grade (p < 0,001).
The components of VAI may have effect on tumor carcinogenesis in similar pathways. In our study patients with high VAI levels were found to have statistically significant higher nuclear grade and tumor size. VAI can be a useful index for the evaluation and calculation of renal cell cancer aggressiviness. Further studies with more patients are needed to confirm our study.
本研究旨在评估肾细胞癌患者肿瘤大小和分级与内脏脂肪指数（VAI）水平之间的关系。
我们回顾性分析了2007年1月至2014年5月在我院接受根治性肾切除术的310例连续性肾细胞癌患者的记录。与之前的研究一样，分别按照公式计算男性和女性的VAI。对肿瘤大小、核分级与VAI水平之间的关系进行统计学评估。分析采用卡方检验和逻辑回归分析完成。
在我们研究分析的310例患者中，男性176例（56.8%），女性134例（43.2%）。肿瘤体积较大的男性和女性的VAI水平在统计学上更高（p<0.001）。富尔曼分级较高的男性和女性的VAI水平在统计学上更高（p<0.001）。
VAI的组成部分可能在相似途径中对肿瘤发生有影响。在我们的研究中，发现VAI水平较高的患者在统计学上具有显著更高的核分级和肿瘤大小。VAI可作为评估和计算肾细胞癌侵袭性的有用指标。需要更多患者参与的进一步研究来证实我们的研究。
