使用表面光学相干断层扫描和吲哚菁绿血管造影术对中心性浆液性脉络膜视网膜病变的病因进行研究。
Investigation of the Etiology of Central Serous Chorioretinopathy Using En-Face Optical Coherence Tomography and Indocyanine Green Angiography.
作者信息
Shinojima Ari, Fujita Kyoko, Mori Ryusaburo, Kawamura Akiyuki, Yuzawa Mitsuko, Yasukawa Tsutomu
机构信息
Division of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, Tokyo, Japan.
出版信息
Ophthalmologica. 2016;236(2):100-7. doi: 10.1159/000448342. Epub 2016 Aug 18.
PURPOSE
To identify locations of hypofluorescent lesions on late-phase indocyanine green angiography (ICGA) in patients with central serous chorioretinopathy (CSC) using en-face optical coherence tomography (OCT).
PROCEDURES
We retrospectively studied 25 consecutive untreated CSC patients, using swept-source OCT and ICGA. En-face swept-source OCT images were automatically segmented and flattened with Bruch's membrane (BrM). We compared the sizes of hyperreflective areas in the 25 CSC and 25 contralateral eyes on en-face images and hypofluorescent areas on ICGA after 30 min.
RESULTS
All 25 CSC eyes and 13 contralateral eyes showed abnormal hypofluorescent areas on late-phase ICGA and hyperreflective areas on en-face OCT from BrM to the choriocapillaris, and these findings correlated with the abnormal areas (r = 0.9988; p < 0.001).
CONCLUSIONS
In CSC patients, we detected abnormal hypofluorescence on ICGA in the late phase, which corresponded to abnormal hyperreflective areas from BrM to the choriocapillaris level in en-face images.
目的
使用表面光学相干断层扫描（OCT）确定中心性浆液性脉络膜视网膜病变（CSC）患者在吲哚菁绿血管造影（ICGA）晚期低荧光病变的位置。
方法
我们回顾性研究了25例未经治疗的连续CSC患者，使用扫频源OCT和ICGA。表面扫频源OCT图像自动分割并以布鲁赫膜（BrM）进行扁平化处理。我们比较了25例CSC患眼和25例对侧眼在表面图像上的高反射区大小以及ICGA 30分钟后的低荧光区大小。
结果
所有25例CSC患眼和13例对侧眼在ICGA晚期显示异常低荧光区，在表面OCT上从BrM到脉络膜毛细血管层显示高反射区，且这些发现与异常区域相关（r = 0.9988；p < 0.001）。
结论
在CSC患者中，我们在ICGA晚期检测到异常低荧光，其对应于表面图像上从BrM到脉络膜毛细血管层水平的异常高反射区。
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