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奥地利2型糖尿病患者疾病管理项目有效性评估——一项基于人群的回顾性队列研究

The Evaluation of the Effectiveness of Austrians Disease Management Program in Patients with Type 2 Diabetes Mellitus - A Population-Based Retrospective Cohort Study.

作者信息

Riedl Regina, Robausch Martin, Berghold Andrea

机构信息

Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.

Controlling Department (ÄIRCON), Lower Austria Health Insurance Fund, St. Pölten, Austria.

出版信息

PLoS One. 2016 Aug 17;11(8):e0161429. doi: 10.1371/journal.pone.0161429. eCollection 2016.

Abstract

AIM

To evaluate the effectiveness of the Austrian Disease Management Program (DMP) 'Therapie aktiv-Diabetes im Griff' for patients with type 2 diabetes mellitus concerning patient-relevant outcomes (mortality, myocardial infarction and stroke) and costs.

METHODS

Based on routine health insurance data, we conducted a population-based retrospective cohort study using a propensity score (PS) matched control group design. The DMP-group consists of participants enrolled in the program during 2008 and 2009 (n = 7181). Out of 208.532 patients with no participation in the DMP up to 2013, PS-matched controls were selected with a matching ratio 1:3. In the PS-model, patient's characteristics, form of antidiabetic drug therapy, several prescriptions, the number of hospital admissions and days, main discharge diagnoses and costs at baseline were included.

RESULTS

Over a follow-up period of four years, we observed a significantly lower mortality rate in the DMP-group (9.4%) in comparison with the control group (15.9%, p<0.001). The cumulative number of hospital days and mean annual hospital costs were lower for DMP-participants resulting in significantly lower mean annual total costs, amounting to € 8226.80 per patient in the DMP-group and € 9231.10 in the control group respectively (p<0.001).

CONCLUSIONS

The evaluation shows a survival benefit and an average reduction of costs for participants in the DMP compared with the control-group. Despite we took great effort to ensure comparable groups, we cannot entirely rule out an influence by residual and unmeasured confounding due to the observational study design and the use of routine data. However, the results indicate that the disease management program implemented in Austria improves quality of care for patients with type 2 diabetes mellitus.

摘要

目的

评估奥地利疾病管理项目(DMP)“积极治疗——掌控糖尿病”对2型糖尿病患者与患者相关结局(死亡率、心肌梗死和中风)及成本的有效性。

方法

基于常规医疗保险数据,我们采用倾向评分(PS)匹配对照组设计进行了一项基于人群的回顾性队列研究。DMP组由2008年和2009年参加该项目的参与者组成(n = 7181)。在截至2013年未参加DMP的208532名患者中,按1:3的匹配比例选择PS匹配对照组。在PS模型中,纳入了患者特征、抗糖尿病药物治疗形式、若干处方、住院次数和天数、主要出院诊断以及基线时的成本。

结果

在四年的随访期内,我们观察到DMP组的死亡率(9.4%)显著低于对照组(15.9%,p<0.001)。DMP参与者的累计住院天数和年均住院成本较低,导致年均总成本显著降低,DMP组每位患者分别为8226.80欧元,对照组为9231.10欧元(p<0.001)。

结论

评估表明,与对照组相比,DMP参与者有生存获益且成本平均降低。尽管我们竭尽全力确保组间可比,但由于观察性研究设计和常规数据的使用,我们不能完全排除残余和未测量混杂因素的影响。然而,结果表明奥地利实施的疾病管理项目改善了2型糖尿病患者的护理质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5487/4988720/ed8620739f76/pone.0161429.g001.jpg

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