Sharabi Sivan, Drori Yaron, Micheli Michal, Friedman Nehemya, Orzitzer Sara, Bassal Ravit, Glatman-Freedman Aharona, Shohat Tamar, Mendelson Ella, Hindiyeh Musa, Mandelboim Michal
Central Virology Laboratory, Ministry of Health, Chaim Sheba Medical Center, Ramat-Gan, 52621, Israel.
Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
PLoS One. 2016 Aug 17;11(8):e0161195. doi: 10.1371/journal.pone.0161195. eCollection 2016.
While influenza A viruses comprise a heterogeneous group of clinically relevant influenza viruses, influenza B viruses form a more homogeneous cluster, divided mainly into two lineages: Victoria and Yamagata. This divergence has complicated seasonal influenza vaccine design, which traditionally contained two seasonal influenza A virus strains and one influenza B virus strain. We examined the distribution of the two influenza B virus lineages in Israel, between 2011-2014, in hospitalized and in non-hospitalized (community) influenza B virus-infected patients. We showed that influenza B virus infections can lead to hospitalization and demonstrated that during some winter seasons, both influenza B virus lineages circulated simultaneously in Israel. We further show that the influenza B virus Yamagata lineage was dominant, circulating in the county in the last few years of the study period, consistent with the anti-Yamagata influenza B virus antibodies detected in the serum samples of affected individuals residing in Israel in the year 2014. Interestingly, we found that elderly people were particularly vulnerable to Yamagata lineage influenza B virus infections.
甲型流感病毒包含一组临床相关的异质性流感病毒，而乙型流感病毒则形成一个更为同质化的群体，主要分为两个谱系：维多利亚谱系和山形谱系。这种差异使季节性流感疫苗的设计变得复杂，传统的季节性流感疫苗包含两种甲型流感病毒株和一种乙型流感病毒株。我们研究了2011年至2014年期间，以色列住院和非住院（社区）乙型流感病毒感染患者中两种乙型流感病毒谱系的分布情况。我们发现乙型流感病毒感染可导致住院，并证明在某些冬季，两种乙型流感病毒谱系在以色列同时传播。我们进一步表明，山形谱系乙型流感病毒占主导地位，在研究期的最后几年在该国传播，这与2014年居住在以色列的受影响个体血清样本中检测到的抗山形谱系乙型流感病毒抗体一致。有趣的是，我们发现老年人特别容易感染山形谱系乙型流感病毒。
