Tohid Hassaan, Aleem Daniyal, Jackson Chantal
Center for Mind and Brain, University of California, Davis, Davis, Calif., USA.
Skin Pharmacol Physiol. 2016;29(4):220-30. doi: 10.1159/000448122. Epub 2016 Aug 19.
The aim of this paper was to highlight the mechanisms involved and the relationship between depression and psoriasis.
A comprehensive literature search was performed in various databases, and finally 88 studies were deemed relevant.
A significant link was found between depression and psoriasis, primarily through immune mechanisms related but not limited to the actions of inflammatory cytokines such as tumor necrosis factor-α, interleukin 1 (IL-1), IL-2, IL-10, interferon-γ, IL-1β, prostaglandin E2, C-reactive protein, IL-6, and IL-8.
Various neuroimmunological studies point towards the notion that depression and psoriasis are associated with each other. Melatonin has also been found to be associated with both conditions. A possibility exists that both conditions can cause each other due to the possible bidirectional relationship of psoriasis and major depression. However, if this is the case, then why all depressed patients fail to develop psoriasis and why all psoriatic patients fail to develop depression remains a question unanswered. We believe that future studies will unmask this mystery.
本文旨在强调抑郁症与银屑病之间的相关机制及关系。
在多个数据库中进行了全面的文献检索，最终确定88项研究相关。
发现抑郁症与银屑病之间存在显著关联，主要通过免疫机制，这些机制与炎症细胞因子如肿瘤坏死因子-α、白细胞介素1（IL-1）、IL-2、IL-10、干扰素-γ、IL-1β、前列腺素E2、C反应蛋白、IL-6和IL-8的作用相关但不限于这些作用。
各种神经免疫学研究表明抑郁症与银屑病相互关联。褪黑素也被发现与这两种情况都有关。由于银屑病和重度抑郁症可能存在双向关系，两种情况有可能相互导致。然而，如果是这样，那么为什么所有抑郁症患者都不会患银屑病，以及为什么所有银屑病患者都不会患抑郁症，仍是一个未解之谜。我们相信未来的研究将揭开这个谜团。
