Maqbool Shahzaib, Ihtesham Arham, Langove Muhammad Nadeem, Jamal Sara, Jamal Tabdar, Safian Hafiz Abu
Department of Medicine, Rawalpindi Medical University, Pakistan.
Department of Haematology, Resident Haematology atomic energy Islamabad, Pakistan.
AIMS Neurosci. 2021 Mar 10;8(3):340-354. doi: 10.3934/Neuroscience.2021018. eCollection 2021.
Our study's motive was to recognize various immune-mediated inflammatory processes involved in the pathogenesis of depression and psoriasis and interlink between them based on inflammatory mediators.
A careful and comprehensive literature search was done through various databases like PubMed, Google Scholar, and EBSCO. A total of 56 studies were included in our study after careful screening.
The immune-mediated inflammatory process was significantly associated with the pathogenesis of both depression and psoriasis. Most of the inflammatory markers involved in Psoriasis (TNF-α, IL-2, IL-6, IL-23, IL-1β, IL-10), and increased serotonin transporters (5-HTT) were also found in the pathogenesis of depression, showing the immune-inflammatory linkage between psoriasis and major depression. Based on immune chemistry, the levels of CD2, CD4, CD8 T-lymphocytes were also found to be raised in both depression and psoriasis, validating their relationship. Hyperactivity of HPA-axis was also found another interlink between them along with reduced melatonin amount.
According to various studies, the neuro-dermatological association between psoriasis and depression is significant. Different immune markers involved in the pathogenesis of depression and psoriasis also show the bidirectional association between them. However, this association between psoriasis and depression is positively correlated, but more work is required to answer why all depressed patients fail to develop psoriasis and why all psoriatic patients fail to develop depression.
本研究的目的是识别参与抑郁症和银屑病发病机制的各种免疫介导的炎症过程，并基于炎症介质确定它们之间的联系。
通过PubMed、谷歌学术和EBSCO等各种数据库进行了仔细而全面的文献检索。经过仔细筛选，共有56项研究纳入我们的研究。
免疫介导的炎症过程与抑郁症和银屑病的发病机制均显著相关。银屑病中涉及的大多数炎症标志物（TNF-α、IL-2、IL-6、IL-23、IL-1β、IL-10）以及血清素转运体（5-HTT）增加在抑郁症发病机制中也有发现，这表明银屑病与重度抑郁症之间存在免疫炎症联系。基于免疫化学，抑郁症和银屑病患者的CD2、CD4、CD8 T淋巴细胞水平也升高，证实了它们之间的关系。还发现HPA轴功能亢进是它们之间的另一个联系，同时褪黑素含量降低。
根据各种研究，银屑病与抑郁症之间的神经皮肤病学关联显著。抑郁症和银屑病发病机制中涉及的不同免疫标志物也显示了它们之间的双向关联。然而，银屑病与抑郁症之间的这种关联呈正相关，但仍需要更多研究来回答为什么所有抑郁症患者都没有患上银屑病，以及为什么所有银屑病患者都没有患上抑郁症。
