Institutes of 1 Neurosurgery.
Infectious Diseases, and.
J Neurosurg. 2017 Aug;127(2):370-373. doi: 10.3171/2016.6.JNS16352. Epub 2016 Aug 19.
The authors report on the first case of the intraventricular administration of tigecycline described in the Western literature. A 22-year-old man developed cerebrospinal fluid infection from an extremely drug-resistant strain of Acinetobacter baumannii as a complication of endoscopic transsphenoidal surgery for the removal of a giant pituitary adenoma. The patient was safely and successfully treated with the prolonged intraventricular administration of tigecycline. Here, the authors provide the schedule details that can be invaluable in treating meningitis from extremely drug-resistant bacterial strains. Intraventricular tigecycline can be a valuable tool against multidrug-resistant central nervous system infections.
作者报告了西文文献中首例描述的替加环素脑室给药的病例。一名 22 岁男性因内镜经蝶窦手术切除巨大垂体腺瘤而并发对极度耐药的鲍曼不动杆菌引起的脑脊液感染。患者通过延长替加环素脑室给药得到了安全和成功的治疗。在此，作者提供了可在治疗极度耐药菌引起的脑膜炎方面具有重要价值的方案细节。脑室给予替加环素可以成为对抗耐多药中枢神经系统感染的有效手段。
