Hatami Hossein, Deihim Tina, Amiri Parisa, Cheraghi Leila, Azizi Fereidoun
School of Public Health, Shahid Beheshti University of Medical Science, Tehran, Iran.
Research Center for Social Determinants of Endocrine Health and Obesity Research Center, Research Institute for Endocrine sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Arch Iran Med. 2016 Aug;19(8):577-83.
Recent studies have shown that metabolic syndrome is associated with poor health-related quality of life (HRQoL). Moreover, it is shown that the prevalence of MetS and impaired glucose regulation, which are shown to have negative impact on HRQoL, overlap. This study aimed to investigate the association between HRQoL and metabolic syndrome (MetS) considering glucose regulation status in a sample of non-diabetic Tehranian adults.
This was a cross-sectional study conducted within the framework of the Tehran Lipid and Glucose Study (TLGS).Logistic regression analysis was used to estimate the odds ratio (OR) with 95% confidence interval (CIs) in normal and impaired glucose regulation. Cochran's Mantel-Haenszel test was used to test the homogeneity of the odds ratios for reporting poor HRQoL in those with MetS in two groups of normal and impaired glucose regulation.
Totally, 946 participants were studied. After adjustment for age and educational level in women, MetS showed a significant negative impact on physical functioning and bodily pain in those with impaired glucose regulation and physical role limitation in normal glucose regulation group. In impaired glucose regulation group, women with MetS were more likely to report poor physical functioning (OR: 2.86, CI: 1.02-2.79), and bodily pain (OR: 2.96 CI: 1.09-8.04). In women with normal glucose regulation, poor physical role limitation was significantly associated with MetS. This association was not seen in men in either group. Based on the test of homogeneity of odds ratio, the association between MetS and HRQoL in those with normal and impaired glucose regulation was different in role physical subscale.
The current study showed that in both normal and impaired glucose regulation groups, MetS was associated with poor physical HRQoL in women but not men.
近期研究表明，代谢综合征与健康相关生活质量（HRQoL）较差有关。此外，研究表明，对HRQoL有负面影响的代谢综合征（MetS）和血糖调节受损的患病率存在重叠。本研究旨在调查非糖尿病德黑兰成年人样本中，考虑血糖调节状态时HRQoL与代谢综合征（MetS）之间的关联。
这是一项在德黑兰血脂与血糖研究（TLGS）框架内进行的横断面研究。采用逻辑回归分析来估计正常和血糖调节受损情况下的比值比（OR）及95%置信区间（CIs）。使用 Cochr an曼特尔 - 亨泽尔检验来检验正常和血糖调节受损两组中患有MetS者报告HRQoL较差的比值比的同质性。
总共研究了946名参与者。在对女性的年龄和教育水平进行调整后，MetS对血糖调节受损者的身体功能和身体疼痛以及正常血糖调节组中的身体角色限制有显著负面影响。在血糖调节受损组中，患有MetS的女性更有可能报告身体功能差（OR：2.86，CI：1.02 - 2.79）和身体疼痛（OR：2.96，CI：1.09 - 8.04）。在血糖调节正常的女性中，身体角色限制差与MetS显著相关。在两组男性中均未发现这种关联。基于比值比同质性检验，在身体角色子量表中正常和血糖调节受损者中MetS与HRQoL之间的关联不同。
当前研究表明，在正常和血糖调节受损组中，MetS与女性而非男性的身体HRQoL差有关。
