Amiri Parisa, Deihim Tina, Nakhoda Kobra, Hasheminia Mitra, Montazeri Ali, Azizi Fereidoun
Research Center for Social Determinants of Endocrine Health and Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Endocrine Research Center, Research Institute for Endocrine sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Arch Iran Med. 2014 Jun;17(6):423-8.
Given the lack of data clarifying the manner in which women with metabolic syndrome (MetS) in different eras of their life perceive their health-related quality of life (HRQoL), this study aimed at investigating the association between MetS and HRQoL in reproductive age and post menopausal women.
This was a cross-sectional study conducted within the framework of Tehran Lipid and Glucose Study (TLGS). Metabolic syndrome was defined according to the Joint Interim Statement (JIS) and HRQoL was assessed using the Short Form Health Survey (SF-36). Logistic regression analysis was used to estimate the odds ratio (OR) of poor HRQoL with 95% confidence intervals (CIs) for reproductive age and post-menopausal women separately and adjusted for confounding variables.
All 603 participants with (n = 340) and without (n = 263) MetS were studied. Overall, in both physical and mental domains, those without MetS had higher scores in all subscales of SF-36 except for vitality, role emotional and mental component summary. Unadjusted odds ratios (95% CI) for poor physical HRQoL were 2.8 (1.7-4.6); (P < 0.001) and 1.5 (0.7-3.4) for the reproductive age and post-menopausal groups, respectively. Compared to the post-menopausal group, the odds ratio of reporting poor HRQoL for reproductive age women was significantly higher, even after adjusting for age (OR: 1.7, 95% CI: 1.0-3.0, P < 0.05).
The results indicate that MetS is associated with poor HRQoL in reproductive age, but not in post-menopausal women, and the association is observed mainly in relation to physical rather than mental health.
鉴于缺乏数据阐明处于不同生命阶段的代谢综合征（MetS）女性如何看待其健康相关生活质量（HRQoL），本研究旨在调查育龄期和绝经后女性中MetS与HRQoL之间的关联。
这是一项在德黑兰血脂与血糖研究（TLGS）框架内进行的横断面研究。根据联合临时声明（JIS）定义代谢综合征，并使用简短健康调查问卷（SF-36）评估HRQoL。采用逻辑回归分析分别估计育龄期和绝经后女性HRQoL较差的优势比（OR）及其95%置信区间（CI），并对混杂变量进行校正。
对所有603名参与者进行了研究，其中患有（n = 340）和未患有（n = 263）MetS。总体而言，在生理和心理领域，未患MetS者在SF-36的所有子量表中的得分均较高，但活力、情感角色和心理综合得分除外。育龄期和绝经后组身体HRQoL较差的未校正优势比（95%CI）分别为2.8（1.7 - 4.6）；（P < 0.001）和1.5（0.7 - 3.4）。与绝经后组相比，即使在调整年龄后，育龄期女性报告HRQoL较差的优势比仍显著更高（OR：1.7，95%CI：1.0 - 3.0，P < 0.05）。
结果表明，MetS与育龄期女性较差的HRQoL相关，但与绝经后女性无关，且这种关联主要体现在生理健康而非心理健康方面。
