哪种肥胖表型与成年男女健康相关生活质量较差相关？德黑兰血脂和血糖研究。
Which obesity phenotypes predict poor health-related quality of life in adult men and women? Tehran Lipid and Glucose Study.
机构信息
Research Center for Social Determinants of Health, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Students' Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
PLoS One. 2018 Sep 12;13(9):e0203028. doi: 10.1371/journal.pone.0203028. eCollection 2018.
PURPOSE
This study aimed to explore the association between different obesity phenotypes and health-related quality of life (HRQoL) among Tehranian men and women.
METHODS
The participants of this study were 2880 healthy adults (aged>19 years) who participated in Tehran Lipid and Glucose Study (TLGS). To obtain socio-demographic and HRQoL information, participants were interviewed by trained interviewers and were stratified by body mass index categories and metabolic status. Dysmetabolic status was defined as having either metabolic syndrome or diabetes according to the Joint Interim Statement definition and American Diabetes Association. Poor HRQoL was defined as the first quartile of HRQoL scores and logistic regression analysis was used to compare sex-specific odds ratios.
RESULTS
Mean age of participants was 47.7±15.6 and 47.8±14.2 years in men and women respectively. The most and the least common obesity phenotypes were overweight-normal metabolic status and normal weight-dysmetabolic status, respectively. Only mean scores for physical HRQoL were significantly different among obesity phenotypes in both men and women (p<0.05). In addition, after adjusting for age, marital status, level of education, job status and physical activity, the odds of reporting poor physical HRQoL was significantly higher in men (OR: 1.960, 95% CI: 1.037-3.704; p<0.05) and women (OR: 2.887, 95% CI: 1.674-4.977; p<0.001) with obese-dysmetabolic status, compared to their counterparts with normal weight-normal metabolic status. However, except for overweight-normal metabolic women, who were less likely to report poor mental HRQoL (OR: 0.638, 95% CI: 0.415-0.981; p<0.05), none of the phenotypes were associated with poor mental HRQoL in either gender.
CONCLUSIONS
Compared to those with normal weight normal metabolic status, only obese dysmetabolic individuals were more likely to report poor physical HRQoL in both genders.
目的
本研究旨在探讨德黑兰男性和女性中不同肥胖表型与健康相关生活质量（HRQoL）之间的关系。
方法
本研究的参与者是 2880 名健康成年人（年龄>19 岁），他们参加了德黑兰血脂和血糖研究（TLGS）。为了获得社会人口统计学和 HRQoL 信息，经过培训的访谈员对参与者进行了访谈，并按体重指数类别和代谢状态进行分层。代谢异常状态根据联合临时声明定义和美国糖尿病协会定义为代谢综合征或糖尿病。生活质量差定义为 HRQoL 评分的第一四分位数，并使用逻辑回归分析比较了性别特异性比值比。
结果
参与者的平均年龄分别为男性 47.7±15.6 岁和女性 47.8±14.2 岁。最常见和最不常见的肥胖表型分别为超重-正常代谢状态和正常体重-代谢异常状态。只有男性和女性的肥胖表型之间的身体 HRQoL 平均得分存在显著差异（p<0.05）。此外，在调整年龄、婚姻状况、教育程度、工作状况和体力活动后，与正常体重-正常代谢状态相比，男性（比值比：1.960，95%置信区间：1.037-3.704；p<0.05）和女性（比值比：2.887，95%置信区间：1.674-4.977；p<0.001）中肥胖-代谢异常状态报告身体 HRQoL 差的可能性显著更高。然而，除了超重-正常代谢的女性不太可能报告精神 HRQoL 差（比值比：0.638，95%置信区间：0.415-0.981；p<0.05）外，没有一种表型与两性的精神 HRQoL 差有关。
结论
与正常体重-正常代谢状态相比，只有肥胖-代谢异常个体在两性中更有可能报告身体 HRQoL 差。
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