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本文引用的文献

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Antiretroviral treatment program retention among HIV-infected children in the Democratic Republic of Congo.抗逆转录病毒治疗方案在刚果民主共和国感染艾滋病毒的儿童中的保留率。
PLoS One. 2014 Dec 26;9(12):e113877. doi: 10.1371/journal.pone.0113877. eCollection 2014.
2
Temporal trends in mortality and loss to follow-up among children enrolled in Côte d'Ivoire's national antiretroviral therapy program.科特迪瓦全国抗逆转录病毒治疗项目登记儿童的死亡率及失访情况的时间趋势。
Pediatr Infect Dis J. 2014 Nov;33(11):1134-40. doi: 10.1097/INF.0000000000000457.
3
High attrition among HIV-infected patients with advanced disease treated in an intermediary referral center in Maputo, Mozambique.莫桑比克马普托中介转诊中心治疗的晚期艾滋病病毒感染患者高流失率。
Glob Health Action. 2014 Apr 8;7:23758. doi: 10.3402/gha.v7.23758. eCollection 2014.
4
Patient retention, clinical outcomes and attrition-associated factors of HIV-infected patients enrolled in Zimbabwe's National Antiretroviral Therapy Programme, 2007-2010.2007 - 2010年参与津巴布韦国家抗逆转录病毒治疗项目的HIV感染患者的留存率、临床结局及与退出相关的因素
PLoS One. 2014 Jan 29;9(1):e86305. doi: 10.1371/journal.pone.0086305. eCollection 2014.
5
Differences between HIV-Infected men and women in antiretroviral therapy outcomes - six African countries, 2004-2012.艾滋病毒感染者在抗逆转录病毒治疗结果方面的差异-六个非洲国家，2004-2012 年。
MMWR Morb Mortal Wkly Rep. 2013 Nov 29;62(47):945-52.
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Outcomes and impact of HIV prevention, ART and TB programs in Swaziland--early evidence from public health triangulation.斯威士兰的艾滋病毒预防、抗逆转录病毒治疗和结核病规划的结果和影响--公共卫生三角测量的早期证据。
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Retention in a NGO supported antiretroviral program in the Democratic Republic of Congo.在刚果民主共和国，非政府组织支持的抗逆转录病毒方案的保持率。
PLoS One. 2012;7(7):e40971. doi: 10.1371/journal.pone.0040971. Epub 2012 Jul 17.
8
Health and functional status among older people with HIV/AIDS in Uganda.乌干达老年艾滋病毒/艾滋病患者的健康和功能状况。
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Suboptimal adherence associated with virological failure and resistance mutations to first-line highly active antiretroviral therapy (HAART) in Bangalore, India.在印度班加罗尔，与一线高效抗逆转录病毒治疗（HAART）相关的病毒学失败和耐药突变有关的不依从性。
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Better antiretroviral therapy outcomes at primary healthcare facilities: an evaluation of three tiers of ART services in four South African provinces.初级保健机构中更好的抗逆转录病毒治疗结果：对南非四个省份的三个艾滋病治疗服务层次的评估。
PLoS One. 2010 Sep 21;5(9):e12888. doi: 10.1371/journal.pone.0012888.

斯威士兰抗逆转录病毒治疗的流失情况：一项基于人群的研究。

Antiretroviral treatment attrition in Swaziland: a population-based study.

作者信息

Khumalo P G, Chou Y J, Pu C

机构信息

Antiretroviral Treatment Unit,Mbabane Government Hospital,Mbabane,Swaziland.

Institute of Public Health, National Yang-Ming University,Taipei,Taiwan.

出版信息

Epidemiol Infect. 2016 Dec;144(16):3474-3482. doi: 10.1017/S0950268816001813. Epub 2016 Aug 22.

DOI:10.1017/S0950268816001813
PMID:27545693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9150204/
Abstract

Swaziland has the highest prevalence of human immunodeficiency virus (HIV) in the world. Attrition (loss to follow-up and mortality) in people living with HIV/AIDS (PLWHA) already on treatment is a major challenge, undermining achievements of the antiretroviral treatment (ART) programme in Swaziland. The contributing factors to attrition in the Swazi context are unclear. This study aims to (1) estimate attrition from the ART programme 12 months after ART initiation in Swaziland, and (2) determine the predictors of attrition in PLWHA treated with ART in Swaziland. A retrospective cohort study using national baseline data was conducted. A competing-risk Cox proportional hazard regression was used to determine the predictors of attrition. We estimated 10·3% (95% confidence interval 10·1-10·6) attrition in 16 423 participants that initiated ART in 2012. Attrition was significantly associated with sex, age, district, treatment supporter at initiation, co-infection of HIV and TB, functional status, WHO clinical stage, and ownership of facility. Our study can form a base of policies, plans, and service delivery strategies for preventing and controlling attrition in Swaziland.

摘要

斯威士兰是世界上人类免疫缺陷病毒（HIV）感染率最高的国家。对已经接受治疗的艾滋病毒/艾滋病患者（PLWHA）而言，人员流失（失访和死亡）是一项重大挑战，有损于斯威士兰抗逆转录病毒治疗（ART）项目所取得的成果。在斯威士兰，导致人员流失的因素尚不清楚。本研究旨在：（1）估计斯威士兰开始接受抗逆转录病毒治疗12个月后ART项目的人员流失情况，以及（2）确定斯威士兰接受抗逆转录病毒治疗的艾滋病毒/艾滋病患者中人员流失的预测因素。利用国家基线数据开展了一项回顾性队列研究。采用竞争风险Cox比例风险回归分析来确定人员流失的预测因素。我们估计，2012年开始接受抗逆转录病毒治疗的16423名参与者中，人员流失率为10.3%（95%置信区间10.1-10.6）。人员流失与性别、年龄、地区、开始治疗时的治疗支持者、艾滋病毒和结核病合并感染、功能状态、世界卫生组织临床分期以及医疗机构所有权显著相关。我们的研究可为斯威士兰预防和控制人员流失的政策、计划及服务提供策略奠定基础。