McElroy Máire C, Hill Martin, Moloney Geraldine, Mac Aogáin Micheál, McGettrick Shane, O'Doherty Áine, Rogers Thomas R
Pathology Division, Central Veterinary Research Laboratory, Backweston Campus, Celbridge, Co. Kildare Ireland.
Department of Clinical Microbiology, Trinity College Dublin, Dublin, Ireland.
Ir Vet J. 2016 Aug 19;69:10. doi: 10.1186/s13620-016-0070-9. eCollection 2015.
Clostridium difficile is a recognised cause of typhlocolitis and diarrhoea in neonatal pigs but has never been confirmed in association with pathology and disease in Irish pigs.
Four neonatal piglets, with a history of diarrhoea were referred to the Central Veterinary Research Laboratory, Backweston for necropsy. They were from a fully integrated, commercial pig farm with approximately 1000 sows. Three piglets had acute, superficial, erosive and suppurative typhlocolitis and the other had mild suppurative mesocolitis. Clostridium difficile (C. difficile) toxins A/B were detected using ELISA in the colonic contents from each piglet. C. difficile isolates from two of the piglets were PCR-ribotyped as 078 and an isolate from a third pig was ribotyped as 110.
This is the first report confirming C. difficile in association with typhlocolitis in Irish pigs.
艰难梭菌是新生仔猪患盲结肠炎和腹泻的已知病因，但在爱尔兰猪中，从未证实其与病理和疾病有关。
四只患有腹泻病史的新生仔猪被转诊至位于巴克韦斯顿的中央兽医研究实验室进行尸检。它们来自一个约有1000头母猪的完全一体化商业养猪场。三只仔猪患有急性、浅表性、糜烂性和化脓性盲结肠炎，另一只患有轻度化脓性结肠系膜炎症。使用酶联免疫吸附测定法（ELISA）在每只仔猪的结肠内容物中检测到艰难梭菌毒素A/B。从两只仔猪分离出的艰难梭菌经聚合酶链反应核糖体分型为078型，从第三只仔猪分离出的菌株核糖体分型为110型。
这是首次证实爱尔兰猪中艰难梭菌与盲结肠炎有关的报告。
