Neumann Wolf-Julian, Degen Katharina, Schneider Gerd-Helge, Brücke Christof, Huebl Julius, Brown Peter, Kühn Andrea A
Department of Neurology, Campus Virchow Klinikum, Charité-University Medicine Berlin, Berlin, Germany.
Department of Neurosurgery, Campus Virchow Klinikum, Charité-University Medicine Berlin, Berlin, Germany.
Mov Disord. 2016 Nov;31(11):1748-1751. doi: 10.1002/mds.26759. Epub 2016 Aug 22.
Beta band oscillations in the subthalamic nucleus (STN) have been proposed as a pathophysiological signature in patients with Parkinson's disease (PD). The aim of this study was to investigate the potential association between oscillatory activity in the STN and symptom severity in PD.
Subthalamic local field potentials were recorded from 63 PD patients in a dopaminergic OFF state. Power-spectra were analyzed for the frequency range from 5 to 95 Hz and correlated with individual UPDRS-III motor scores in the OFF state.
A correlation between total UPDRS-III scores and 8 to 35 Hz activity was revealed across all patients (ρ = 0.44, P < .0001). When correlating each frequency bin, a narrow range from 10 to 15 Hz remained significant for the correlation (false discovery rate corrected P < .05).
Our results show a correlation between local STN 8 to 35 Hz power and impairment in PD, further supporting the role of subthalamic oscillatory activity as a potential biomarker for PD.
丘脑底核(STN)中的β波段振荡已被认为是帕金森病(PD)患者的一种病理生理特征。本研究的目的是探讨STN中的振荡活动与PD患者症状严重程度之间的潜在关联。
记录63例处于多巴胺能失活状态的PD患者的丘脑底核局部场电位。分析5至95Hz频率范围内的功率谱,并与失活状态下的个体统一帕金森病评定量表第三部分(UPDRS-III)运动评分相关联。
在所有患者中,总UPDRS-III评分与8至35Hz活动之间存在相关性(ρ = 0.44,P <.0001)。当对每个频率区间进行相关性分析时,10至15Hz的窄范围仍具有显著相关性(错误发现率校正后P <.05)。
我们的结果表明,局部STN的8至35Hz功率与PD中的功能障碍之间存在相关性,进一步支持了丘脑底核振荡活动作为PD潜在生物标志物的作用。