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本文引用的文献

1
Design and Evaluation of Voriconazole Eye Drops for the Treatment of Fungal Keratitis.伏立康唑滴眼液治疗真菌性角膜炎的设计与评价
J Pharm (Cairo). 2014;2014:490595. doi: 10.1155/2014/490595. Epub 2014 Apr 29.
2
Re-appraisal of topical 1% voriconazole and 5% natamycin in the treatment of fungal keratitis in a randomised trial.在一项随机试验中对局部用1%伏立康唑和5%那他霉素治疗真菌性角膜炎的重新评估。
Br J Ophthalmol. 2015 Sep;99(9):1190-5. doi: 10.1136/bjophthalmol-2014-306485. Epub 2015 Mar 4.
3
Clinical utility of caspofungin eye drops in fungal keratitis.卡泊芬净滴眼液在真菌性角膜炎中的临床应用。
Int J Antimicrob Agents. 2014 Aug;44(2):96-104. doi: 10.1016/j.ijantimicag.2014.04.008. Epub 2014 May 17.
4
Pharmacoeconomics of voriconazole in the management of invasive fungal infections.伏立康唑治疗侵袭性真菌感染的药物经济学评价。
Expert Rev Pharmacoecon Outcomes Res. 2010 Dec;10(6):623-36. doi: 10.1586/erp.10.69.
5
Single and multidose ocular kinetics and stability analysis of extemporaneous formulation of topical voriconazole in humans.单剂量和多剂量眼部药代动力学和局部伏立康唑临时制剂在人体中的稳定性分析。
Curr Eye Res. 2010 Nov;35(11):953-60. doi: 10.3109/02713683.2010.506968.
6
Stability of extemporaneously prepared voriconazole ophthalmic solution.临时配制的伏立康唑滴眼液的稳定性。
Am J Health Syst Pharm. 2009 Aug 15;66(16):1478-83. doi: 10.2146/ajhp080110.
7
Prospective open-label study of the administration of two-percent voriconazole eye drops.2%伏立康唑滴眼液给药的前瞻性开放标签研究。
Antimicrob Agents Chemother. 2009 Jul;53(7):3153-5. doi: 10.1128/AAC.01700-08. Epub 2009 May 11.
8
Penetration of voriconazole, 1%, eyedrops into human aqueous humor: a prospective open-label study.1%伏立康唑滴眼液在人房水中的渗透：一项前瞻性开放标签研究。
Arch Ophthalmol. 2008 Mar;126(3):343-6. doi: 10.1001/archophthalmol.2007.71.
9
Aqueous and vitreous concentrations following topical administration of 1% voriconazole in humans.人类局部应用1%伏立康唑后的房水和玻璃体浓度。
Arch Ophthalmol. 2008 Jan;126(1):18-22. doi: 10.1001/archophthalmol.2007.8.
10
Voriconazole concentration in human aqueous humor and plasma during topical or combined topical and systemic administration for fungal keratitis.局部或局部与全身联合给药治疗真菌性角膜炎时人房水和血浆中的伏立康唑浓度。
Antimicrob Agents Chemother. 2007 Jan;51(1):239-44. doi: 10.1128/AAC.00762-06. Epub 2006 Oct 23.

1%伏立康唑滴眼液吸收与清除的开放标签研究。

Open-Label Study of Absorption and Clearance of 1% Voriconazole Eye Drops.

作者信息

Neoh Chin Fen, Leung Lok, Chan Elsie, Al-Badriyeh Daoud, Fullinfaw Robert O, Jhanji Vishal, Vajpayee Rasik B, Davies Geoffrey E, Stewart Kay, Kong David C M

机构信息

Collaborative Drug Discovery Research (CDDR) Group, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam, Selangor, Malaysia.

Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

出版信息

Antimicrob Agents Chemother. 2016 Oct 21;60(11):6896-6898. doi: 10.1128/AAC.00683-16. Print 2016 Nov.

DOI:10.1128/AAC.00683-16
PMID:27550348
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5075102/
Abstract

Twenty participants undergoing elective cataract surgery received 1% voriconazole eye drops (1 drop per eye) either 20, 40, 60, or 80 min before surgery. Median voriconazole concentrations of 1.9 to 3.2 mg/liter in aqueous humor samples were attained over the first 80 min, which were higher than in vitro MIC values for typical fungi that cause keratitis.

摘要

20名接受择期白内障手术的参与者在手术前20、40、60或80分钟接受1%伏立康唑滴眼液（每只眼睛滴1滴）。在最初的80分钟内，房水样本中伏立康唑的中位浓度达到1.9至3.2毫克/升，高于引起角膜炎的典型真菌的体外最低抑菌浓度值。