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口服葡萄糖耐量试验中年轻健康瘦人和肥胖非糖尿病男性的血清甘丙肽水平。

Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test.

机构信息

Department of Internal Medicine-Division of Endocrinology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.

Department of Physiology, School of Medicine, Universidad Nacional de Colombia Bogotá, Colombia.

出版信息

Sci Rep. 2016 Aug 23;6:31661. doi: 10.1038/srep31661.

DOI:10.1038/srep31661
PMID:27550417
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4994037/
Abstract

Galanin (GAL) is a neuropeptide involved in the homeostasis of energy metabolism. The objective of this study was to investigate the serum levels of GAL during an oral glucose tolerance test (OGTT) in lean and obese young men. This cross-sectional study included 30 obese non-diabetic young men (median 22 years; mean BMI 37 kg/m(2)) and 30 healthy lean men (median 23 years; mean BMI 22 kg/m(2)). Serum GAL was determined during OGTT. The results of this study include that serum GAL levels showed a reduction during OGTT compared with basal levels in the lean subjects group. Conversely, serum GAL levels increased significantly during OGTT in obese subjects. Serum GAL levels were also higher in obese non-diabetic men compared with lean subjects during fasting and in every period of the OGTT (p < 0.001). Serum GAL levels were positively correlated with BMI, total fat, visceral fat, HOMA-IR, total cholesterol, triglycerides and Leptin. A multiple regression analysis revealed that serum insulin levels at 30, 60 and 120 minutes during the OGTT is the most predictive variable for serum GAL levels (p < 0.001). In conclusion, serum GAL levels are significantly higher in the obese group compared with lean subjects during an OGTT.

摘要

甘丙肽（GAL）是一种参与能量代谢稳态的神经肽。本研究的目的是在瘦人和肥胖年轻男性的口服葡萄糖耐量试验（OGTT）期间检测血清 GAL 水平。这项横断面研究包括 30 名肥胖非糖尿病年轻男性（中位数 22 岁；平均 BMI 37kg/m²）和 30 名健康瘦男性（中位数 23 岁；平均 BMI 22kg/m²）。在 OGTT 期间测定血清 GAL。研究结果表明，与瘦组相比，OGTT 期间血清 GAL 水平较基础水平降低。相反，OGTT 期间肥胖组的血清 GAL 水平显著升高。在禁食和 OGTT 的每个时期，肥胖非糖尿病男性的血清 GAL 水平均高于瘦男性（p<0.001）。血清 GAL 水平与 BMI、总脂肪、内脏脂肪、HOMA-IR、总胆固醇、甘油三酯和瘦素呈正相关。多元回归分析显示，OGTT 期间 30、60 和 120 分钟的血清胰岛素水平是预测血清 GAL 水平的最具预测性变量（p<0.001）。总之，在 OGTT 期间，肥胖组的血清 GAL 水平明显高于瘦组。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d94/4994037/7abdfac3d0c9/srep31661-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d94/4994037/fd36e9999eec/srep31661-f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d94/4994037/778e8c1b6e41/srep31661-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d94/4994037/7d8048eeb69e/srep31661-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d94/4994037/7abdfac3d0c9/srep31661-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d94/4994037/fd36e9999eec/srep31661-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d94/4994037/e82401330686/srep31661-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d94/4994037/ac6dea9346dc/srep31661-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d94/4994037/778e8c1b6e41/srep31661-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d94/4994037/7d8048eeb69e/srep31661-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d94/4994037/7abdfac3d0c9/srep31661-f6.jpg

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