Department of Cell Biology, University Medical Center Groningen, University of Groningen, Ant. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Department of Biochemistry, Stellenbosch University, Private Bag X1, Matieland, Stellenbosch 7602, South Africa.
Nat Rev Mol Cell Biol. 2016 Oct;17(10):605-6. doi: 10.1038/nrm.2016.110. Epub 2016 Aug 24.
The consensus has been that intracellular coenzyme A (CoA) is obtained exclusively by de novo biosynthesis via a universal, conserved five-step pathway in the cell cytosol. However, old and new evidence suggest that cells (and some microorganisms) have several strategies to obtain CoA, with 4'-phosphopantetheine (P-PantSH; the fourth intermediate in the canonical CoA biosynthetic pathway) serving as a 'nexus' metabolite.
人们普遍认为，细胞内辅酶 A（CoA）只能通过细胞胞质溶胶中普遍存在且保守的五步骤途径从头合成获得。然而，新旧证据表明，细胞（和一些微生物）有几种获得 CoA 的策略，4'-磷酸泛酰巯基乙胺（P-PantSH；经典 CoA 生物合成途径中的第四个中间产物）作为一种“枢纽”代谢物。
