Jung Yoon Suk, Lee Chang Kyun, Eun Chang Soo, Park Dong Il, Han Dong Soo, Kim Hyo Jong
Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Digestion. 2016;94(2):82-91. doi: 10.1159/000448887. Epub 2016 Aug 24.
Minimal data exist regarding the use of low-volume purgatives for elderly (≥65 years) patients. We aimed to investigate the bowel-cleansing efficacy and patient tolerability of split-dose 2 liters (L)-polyethylene glycol with ascorbic acid (2L-PEGA) in elderly outpatients undergoing colonoscopy.
Patients who underwent morning colonoscopies were randomly assigned to one of 3 arms: single-dose 4L-PEG on the day before colonoscopy; split-dose 4L-PEG; or split-dose 2L-PEGA. The quality of bowel preparation was assessed using the Boston Bowel Preparation Scale (BBPS).
Of 230 patients enrolled, 198 were analyzed. The proportion of adequate bowel preparations in split-dose 2L-PEGA was higher than that in single-dose 4L-PEG (92.1 vs. 75.0%, p = 0.009) and similar to split-dose 4L-PEG. The mean BBPS scores for global and right colon preparation in the split-dose 2L-PEGA were comparable to split-dose 4L-PEG but higher than those in the single-dose 4L-PEG. The proportion of patients who ingested the entire volume of solution in 2L-PEGA was higher than that in single-dose 4L-PEG (96.8 vs. 80.9%, p = 0.011). Patients receiving 2L-PEGA expressed more willingness to repeat the same preparation than other groups. The rate of adverse events did not differ among the 3 groups.
Split-dose 2L-PEGA was an effective, safe, and comfortable method for colonoscopy preparation in elderly outpatients.
关于老年（≥65岁）患者使用小剂量泻药的数据极少。我们旨在研究分剂量2升（L）聚乙二醇加抗坏血酸（2L - PEGA）用于老年门诊患者结肠镜检查的肠道清洁效果及患者耐受性。
接受上午结肠镜检查的患者被随机分为3组之一：结肠镜检查前一天单剂量4L - PEG；分剂量4L - PEG；或分剂量2L - PEGA。使用波士顿肠道准备量表（BBPS）评估肠道准备质量。
在纳入的230例患者中，198例进行了分析。分剂量2L - PEGA组充分肠道准备的比例高于单剂量4L - PEG组（92.1%对75.0%，p = 0.009），且与分剂量4L - PEG组相似。分剂量2L - PEGA组整体和右半结肠准备的平均BBPS评分与分剂量4L - PEG组相当，但高于单剂量4L - PEG组。2L - PEGA组摄入全部溶液的患者比例高于单剂量4L - PEG组（96.8%对80.9%，p = 0.011）。接受2L - PEGA的患者比其他组更愿意重复相同的准备方法。3组之间不良事件发生率无差异。
分剂量2L - PEGA是老年门诊患者结肠镜检查准备的一种有效、安全且舒适的方法。
