基因多态性作为肥胖女性 Roux-en-Y 胃旁路手术后体重减轻的预测指标。
Gene polymorphisms as a predictor of body weight loss after Roux-en-Y gastric bypass surgery among obese women.
作者信息
Novais Patrícia Fátima Souza, Weber Thabata Koester, Lemke Ney, Verlengia Rozangela, Crisp Alex Harley, Rasera-Junior Irineu, de Oliveira Maria Rita Marques
机构信息
Post-graduate Program in Food and Nutrition, São Paulo State University (UNESP), Araraquara, SP, Brazil.
Post-graduate Program in Food and Nutrition, São Paulo State University (UNESP), Araraquara, SP, Brazil; Institute of Biosciences, São Paulo State University (UNESP), Botucatu, SP, Brazil.
出版信息
Obes Res Clin Pract. 2016 Nov-Dec;10(6):724-727. doi: 10.1016/j.orcp.2016.07.002. Epub 2016 Aug 21.
This study aimed to investigate the association between twelve gene polymorphisms and body weight loss, 12 months after Roux-en-Y gastric bypass (RYGB) surgery. Three hundred and fifty-one obese women participated in this study. The statistical software WEKA was used to identify which gene polymorphisms were potential predictors of postoperative percentage of excess weight loss (%EWL). Our results indicate that the only gene polymorphism that predicted %EWL was rs3813929, which is related to the serotonin receptor gene (5-HT2C). Therefore, the 5-HT2C gene polymorphism rs3813929 (more specifically, the TT genotype) predicted greater %EWL 12 months after RYGB surgery among female patients.
本研究旨在调查Roux-en-Y胃旁路术（RYGB）后12个月，12种基因多态性与体重减轻之间的关联。351名肥胖女性参与了本研究。使用统计软件WEKA来确定哪些基因多态性是术后超重减轻百分比（%EWL）的潜在预测指标。我们的结果表明，唯一能预测%EWL的基因多态性是rs3813929，它与血清素受体基因（5-HT2C）有关。因此，5-HT2C基因多态性rs3813929（更具体地说，TT基因型）在RYGB手术后12个月预测女性患者有更高的%EWL。
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