Institute of Biosciences, Universidade Estadual Paulista Júlio de Mesquita Filho, Botucatu, São Paulo, Brazil.
Human Performance Laboratory, Universidade Metodista de Piracicaba, Piracicaba, São Paulo, Brazil.
J Hum Nutr Diet. 2022 Aug;35(4):739-747. doi: 10.1111/jhn.12984. Epub 2022 Jan 18.
The present study aimed to investigate the influence of food intake on body weight loss (WL) and the association of gene polymorphisms, 1 year after Roux-en-Y gastric bypass (RYGB) surgery.
In total, 95 obese women (age ranged 20-50 years) in a Brazilian cohort underwent RYGB surgery and completed the study. Anthropometric measurements and food intake were assessed before and 1 year after surgery. Twelve gene polymorphisms (GHRL rs26802; GHSR rs572169; LEP rs7799039; LEPR rs1137101; 5-HT2C rs3813929; UCP2 rs659366; UCP2 rs660339; UCP3 rs1800849; SH2B1 rs7498665; TAS1R2 rs35874116; TAS1R2 rs9701796; and FTO rs9939609) were determined using a real-time polymerase chain reaction and a TaqMan assay. The subjects were divided into quartiles regarding percentage of excess weight loss (%EWL). The effect of genetic variants on energy and macronutrient intake was evaluated by simple logistic regression, followed by multiple logistic regression.
Subjects in the first and second quartiles showed a higher initial body mass index. Energy and macronutrient intake before and 1 year after RYGB surgery did not differ between the %EWL quartiles. None of gene polymorphisms investigated showed an association with the estimated energy intake 1 year after surgery.
In conclusion, the estimate energy and food intake did not predict a greater body WL 1 year after RYGB surgery. In addition, the 12 gene polymorphism investigated did not affect the energy intake among female patients.
本研究旨在探讨饮食摄入对体重减轻（WL）的影响以及罗伊氏胃旁路术（RYGB）术后 1 年基因多态性的相关性。
在巴西队列中，共有 95 名年龄在 20-50 岁之间的肥胖女性接受了 RYGB 手术并完成了研究。在手术前和手术后 1 年评估了人体测量学测量和食物摄入量。使用实时聚合酶链反应和 TaqMan 测定法确定了 12 个基因多态性（GHRL rs26802；GHSR rs572169；LEP rs7799039；LEPR rs1137101；5-HT2C rs3813929；UCP2 rs659366；UCP2 rs660339；UCP3 rs1800849；SH2B1 rs7498665；TAS1R2 rs35874116；TAS1R2 rs9701796；和 FTO rs9939609）。根据超重减轻百分比（%EWL）将受试者分为四分之一。通过简单逻辑回归，然后是多元逻辑回归，评估遗传变异对能量和宏量营养素摄入的影响。
第一和第二四分位数的受试者初始体重指数较高。RYGB 手术后前和手术后 1 年的能量和宏量营养素摄入量在 EWL 四分位数之间没有差异。在所研究的 12 个基因多态性中，没有一个与术后 1 年估计的能量摄入量相关。
总之，估计的能量和食物摄入量不能预测 RYGB 手术后 1 年的体重 WL 更大。此外，所研究的 12 个基因多态性并未影响女性患者的能量摄入。
