血清生长分化因子11（GDF11）浓度升高与中国老年本土女性骨质疏松症的高患病率相关。
Increased serum GDF11 concentration is associated with a high prevalence of osteoporosis in elderly native Chinese women.
作者信息
Jin Miaomiao, Song Shumin, Guo Lijuan, Jiang Tiejian, Lin Zhang-Yuan
机构信息
Department of Orthopedics, The Xiangya Hospital of Central South University, Changsha, Hunan, China.
Department of Endocrinology, The Heji Affiliated Hospital of Changzhi Medical College, Changsha, Hunan, China.
出版信息
Clin Exp Pharmacol Physiol. 2016 Nov;43(11):1145-1147. doi: 10.1111/1440-1681.12651.
Osteoporosis is an age-related disease. Many studies have confirmed the anti-aging effect of growth differentiation factor 11 (GDF11), but the action of GDF11 on bone metabolism remains unclear. In this study, we aimed to investigate the relationship between serum GDF11 levels and the prevalence of osteoporosis. Our data indicate negative correlations between serum GDF11 levels and BMD at the lumbar spine and femoral neck. The serum GDF11 levels were grouped into quartile intervals, and the prevalence and risk of osteoporosis were found be markedly greater with increased GDF11 levels. This study demonstrated that GDF11 was negatively correlated with BMD in elderly Chinese women. Furthermore, osteoporotic risk was significantly increased with increases in GDF11 levels.
骨质疏松症是一种与年龄相关的疾病。许多研究已经证实了生长分化因子11（GDF11）的抗衰老作用，但GDF11对骨代谢的作用仍不清楚。在本研究中，我们旨在探讨血清GDF11水平与骨质疏松症患病率之间的关系。我们的数据表明血清GDF11水平与腰椎和股骨颈骨密度呈负相关。将血清GDF11水平分为四分位数区间，发现随着GDF11水平升高，骨质疏松症的患病率和风险显著增加。本研究表明，在中国老年女性中，GDF11与骨密度呈负相关。此外，随着GDF11水平的升高，骨质疏松风险显著增加。
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