Chemistry and Life Science School, Advanced Institute of Materials Science, Changchun University of Technology , 2055 Yanan Street, Changchun, Jilin 130012, P. R. China.
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , 5625 Renmin Street, Changchun, Jilin 130022, P. R. China.
ACS Appl Mater Interfaces. 2016 Sep 14;8(36):23533-41. doi: 10.1021/acsami.6b07453. Epub 2016 Aug 31.
It is an emerging focus to develop a simple and straightforward strategy to synthesize multifunctional nanomedicines for cancer imaging and treatment. In this work, a new carbon dot (named CyCD) with intrinsic theranostic properties was prepared from a hydrophobic cyanine dye [2-((E)-2-((E)-2-chloro-3-((E)-2-(1-(2-hydroxyethyl)-3,3-dimethylindolin-2-ylidene) ethylidene)cyclohex-1-en-1-yl)vinyl)-1-(2-hydroxyethyl)-3,3-dimethyl-3H-indol-1-ium iodide, CyOH] and poly(ethylene glycol) (PEG800) via a simple solvothermal process. The as-prepared CyCD is well dispersed in water media with an average diameter of 2.9 ± 0.5 nm; it possesses favorable hydrophilicity and excellent photostability. More importantly, the strong absorption and near-IR (NIR) emission within the range from 600 to 900 nm, along with preferential uptake at tumors and high photothermal conversion efficiency (η = 38.7%), facilitate CyCD to act as an ideal theranostic agent for NIR fluorescent imaging and photothermal therapy in vitro and in vivo. This work highlights theranostic CDs as an excellent candidate for efficient cancer imaging and therapy.
开发一种简单直接的策略来合成用于癌症成像和治疗的多功能纳米药物是一个新兴的焦点。在这项工作中，我们从疏水性菁染料[2-((E)-2-((E)-2-氯-3-((E)-2-(1-(2-羟乙基)-3,3-二甲基吲哚啉-2-亚基)亚乙基)环己-1-烯-1-基)乙烯基)-1-(2-羟乙基)-3,3-二甲基-3H-吲哚-1-翁碘化物，CyOH]和聚乙二醇(PEG800)通过简单的溶剂热法制备了一种具有内在治疗诊断特性的新型碳点(命名为 CyCD)。所制备的 CyCD 在水中具有良好的分散性，平均直径为 2.9±0.5nm; 它具有良好的亲水性和优异的光稳定性。更重要的是，在 600 至 900nm 的范围内具有强吸收和近红外(NIR)发射，以及在肿瘤部位的优先摄取和高光热转换效率(η=38.7%)，使 CyCD 能够作为 NIR 荧光成像和光热治疗的理想治疗诊断剂在体外和体内发挥作用。这项工作突出了治疗诊断 CD 作为高效癌症成像和治疗的优秀候选者。
