Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Talanta. 2018 Jul 1;184:50-57. doi: 10.1016/j.talanta.2018.02.093. Epub 2018 Feb 27.
It is a great challenge to develop multifunctional nanocarriers for cancer diagnosis and therapy. Herein, versatile CDs/ICG-uLDHs nanovehicles for triple-modal fluorescence/photoacoustic/two-photon bioimaging and effective photothermal therapy were prepared via a facile self-assembly of red emission carbon dots (CDs), indocyanine green (ICG) with the ultrathin layered double hydroxides (uLDHs). Due to the J-aggregates of ICG constructed in the self-assembly process, CDs/ICG-uLDHs was able to stabilize the photothermal agent ICG and enhanced its photothermal efficiency. Furthermore, the unique confinement effect of uLDHs has extended the fluorescence lifetime of CDs in favor of bioimaging. Considering the excellent in vitro and in vivo phototherapeutics and multimodal imaging effects, this work provides a promising platform for the construction of multifunctional theranostic nanocarrier system for the cancer treatment.
开发用于癌症诊断和治疗的多功能纳米载体是一项巨大的挑战。在此，通过简便的自组装将具有红色发射的碳点（CDs）、吲哚菁绿（ICG）与超薄层状双氢氧化物（uLDHs）制备了多功能 CDs/ICG-uLDHs 纳米载体，用于三模式荧光/光声/双光子生物成像和有效的光热治疗。由于 ICG 中的 J-聚集体在自组装过程中构建，因此 CDs/ICG-uLDHs 能够稳定光热试剂 ICG 并提高其光热效率。此外，uLDHs 的独特限制效应延长了 CDs 的荧光寿命，有利于生物成像。鉴于优异的体外和体内光疗和多模式成像效果，这项工作为构建用于癌症治疗的多功能治疗诊断纳米载体系统提供了一个有前途的平台。
