Tejada Silvia, Martorell Miquel, Capo Xavier, Tur Josep A, Pons Antoni, Sureda Antoni
Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands, Ctra. Valldemossa, km 7.5, E-07122 - Palma de Mallorca, Balearic Islands, Spain.
Curr Top Med Chem. 2017;17(4):391-398. doi: 10.2174/1568026616666160824102322.
Cardiovascular disease is the main cause of death in the developed countries. Dyslipidaemia is one of the risk factors associated to cardiovascular disease and it is characterised by abnormal amounts of lipids (i.e. cholesterol and fatty acids) and/or circulating lipoproteins in the blood. Oxidative stress has been implicated in the pathogenesis of various illnesses including cardiovascular disease. In this way, the potential therapeutic or preventive effects of antioxidant mediators have recently drawn much attention. Coumarin (1,2-benzopyrone) is a natural phenolic compound found in many plants such as citrus fruits, tomatoes, vegetables and green tea. Coumarin and derivates are proposed as lipid lowering agents due to its broad pharmacological activities, mainly the implicated in vasodilator and antioxidant effect. Several studies have evidenced a promising role of coumarin and several of its derivates as lipid lowering agents. In the current work, the available reports related to the promising function of these compounds are reviewed.
心血管疾病是发达国家的主要死因。血脂异常是与心血管疾病相关的危险因素之一，其特征是血液中脂质（即胆固醇和脂肪酸）和/或循环脂蛋白的含量异常。氧化应激与包括心血管疾病在内的各种疾病的发病机制有关。因此，抗氧化介质的潜在治疗或预防作用最近备受关注。香豆素（1,2-苯并吡喃）是一种天然酚类化合物，存在于许多植物中，如柑橘类水果、番茄、蔬菜和绿茶。香豆素及其衍生物因其广泛的药理活性，主要是血管舒张和抗氧化作用，被提议作为降脂剂。多项研究证明香豆素及其几种衍生物作为降脂剂具有良好的前景。在当前的工作中，对与这些化合物的潜在功能相关的现有报告进行了综述。
