Damian E, Ianăş O, Bădescu I
C. I. Parhon Institute of Endocrinology, Bucharest, Romania.
Endocrinologie. 1989 Jan-Mar;27(1):9-16.
The effect of the pineal extract and that of two fractions, f1 and f2, one above, the other 10,000 daltons obtained by ultrafiltration of the extract, on HDL-cholesterol as well as on cholesterolemia and testosterone, under basal conditions and under exogenous HCG stimulation was followed up. Under basal conditions, the pineal extract induced a statistically significant decrease in the 3 biochemical indices, an effect which was also recorded with the two fractions, with the difference that the effect of f2 is more intense and significant as compared to f1, whereas the effect of the pineal extract appears more intense than that of the fractions. Under exogenous HCG stimulation, the pineal extract and less the fractions, partly inhibited the lowering effect of HCG on cholesterol and the rising effect of this hormone on testosterone. The role of the equilibrating agent of the pineal extract on HDL-cholesterol, cholesterolemia and testosterone, is discussed.
对松果体提取物以及通过对该提取物进行超滤获得的两个级分（f1和f2，一个分子量高于10,000道尔顿，另一个低于10,000道尔顿）在基础条件下以及外源性人绒毛膜促性腺激素（HCG）刺激下对高密度脂蛋白胆固醇（HDL-胆固醇）、胆固醇血症和睾酮的影响进行了跟踪研究。在基础条件下，松果体提取物使这三项生化指标出现统计学上的显著下降，两个级分也记录到了这种效应，不同的是，与f1相比，f2的效应更强且更显著，而松果体提取物的效应似乎比级分的效应更强。在外源性HCG刺激下，松果体提取物以及程度稍轻的级分部分抑制了HCG对胆固醇的降低作用以及该激素对睾酮的升高作用。讨论了松果体提取物对HDL-胆固醇、胆固醇血症和睾酮的平衡作用。
