Ono Takashi, Mori Yosai, Nejima Ryohei, Tokunaga Tadatoshi, Miyata Kazunori, Amano Shiro
Miyata Eye Hospital, 6-3 Kuraharacho, Miyakonojo, Miyazaki, 885-0051, Japan.
Inouye Eye Hospital, 4-3 Kandasurugadai, Chiyoda-ku, Tokyo, 101-0062, Japan.
Graefes Arch Clin Exp Ophthalmol. 2016 Dec;254(12):2425-2430. doi: 10.1007/s00417-016-3483-y. Epub 2016 Aug 26.
To conduct a long-term follow-up study evaluating the efficacy and safety of transplantation of preserved limbal allograft and amniotic membrane for recurrent pterygium.
This was a retrospective, non-comparative, interventional case series conducted at a private eye hospital. Eighty-four eyes of 80 patients with recurrent pterygium were included in the study. The mean number of previous surgeries for pterygium was 1.36 ± 0.98 (range, 1-8). All subjects received transplantation of preserved limbal allograft and amniotic membrane.
The mean follow-up period was 73.0 ± 38.1 months (range, 12-154 months). Pterygium recurred in 10 eyes (11.9 %). The mean period to recurrence was 16.3 ± 11.3 months (range, 5-33 months). Symblepharon was cured in 21 eyes, persisted in 2 eyes, and newly occurred in 3 eyes. Diplopia was cured in eight eyes, persisted in five eyes, and newly occurred in one eye. As for complications, intraocular pressure elevations over 21 mmHg were recognized in ten eyes of nine cases, in which the intraocular pressure was controlled by reduction of topical steroid in four eyes and by addition of topical prostaglandin derivatives in six eyes. Twenty-four eyes (28.6 %) gained two lines or more of Landolt best spectacle-corrected visual acuity (BSCVA), 56 eyes (66.7 %) stayed within one line from preoperation, and four eyes (4.8 %) lost two lines or more. There were no major complications and no graft rejection.
Transplantation of preserved limbal allograft and amniotic membrane is a safe and effective procedure for recurrent pterygium.
进行一项长期随访研究，评估保存的同种异体角膜缘移植联合羊膜移植治疗复发性翼状胬肉的疗效和安全性。
这是一项在一家私立眼科医院进行的回顾性、非对照、干预性病例系列研究。研究纳入了80例复发性翼状胬肉患者的84只眼。翼状胬肉既往手术的平均次数为1.36±0.98次（范围为1 - 8次）。所有受试者均接受了保存的同种异体角膜缘移植联合羊膜移植。
平均随访期为73.0±38.1个月（范围为12 - 154个月）。10只眼（11.9%）翼状胬肉复发。复发的平均时间为16.3±11.3个月（范围为5 - 33个月）。21只眼睑球粘连治愈，2只眼持续存在，3只眼新发生。8只眼复视治愈，5只眼持续存在，1只眼新发生。至于并发症，9例中的10只眼眼压升高超过21 mmHg，其中4只眼通过减少局部类固醇药物控制眼压，6只眼通过加用局部前列腺素衍生物控制眼压。24只眼（28.6%）最佳矫正视力（BSCVA）提高了两行或更多，56只眼（66.7%）与术前相比视力变化在一行以内，4只眼（4.8%）视力下降了两行或更多。未发生重大并发症和移植排斥反应。
保存的同种异体角膜缘移植联合羊膜移植治疗复发性翼状胬肉是一种安全有效的手术方法。
