Wagner Rabea M, Kricks Lara, Lopez Daniel
Research Centre for Infectious Diseases (ZINF), University of Würzburg, 97080, Würzburg, Germany.
Institute for Molecular Infection Biology (IMIB), University of Würzburg, 97080, Würzburg, Germany.
J Membr Biol. 2017 Aug;250(4):367-378. doi: 10.1007/s00232-016-9923-0. Epub 2016 Aug 26.
Membrane organization is usually associated with the correct function of a number of cellular processes in eukaryotic cells as diverse as signal transduction, protein sorting, membrane trafficking, or pathogen invasion. It has been recently discovered that bacterial membranes are able to compartmentalize their signal transduction pathways in functional membrane microdomains (FMMs). In this review article, we discuss the biological significance of the existence of FMMs in bacteria and comment on possible beneficial roles that FMMs play on the harbored signal transduction cascades. Moreover, four different membrane-associated signal transduction cascades whose functions are linked to the integrity of FMMs are introduced, and the specific role that FMMs play in stabilizing and promoting interactions of their signaling components is discussed. Altogether, FMMs seem to play a relevant role in promoting more efficient activation of signal transduction cascades in bacterial cells and show that bacteria are more sophisticated organisms than previously appreciated.
膜组织通常与真核细胞中许多细胞过程的正确功能相关，这些过程包括信号转导、蛋白质分选、膜运输或病原体入侵等。最近发现，细菌膜能够在功能性膜微区（FMMs）中对其信号转导途径进行区室化。在这篇综述文章中，我们讨论了细菌中FMMs存在的生物学意义，并评论了FMMs在其所承载的信号转导级联反应中可能发挥的有益作用。此外，还介绍了四种与膜相关的信号转导级联反应，其功能与FMMs的完整性相关，并讨论了FMMs在稳定和促进其信号成分相互作用方面所起的具体作用。总之，FMMs似乎在促进细菌细胞中信号转导级联反应更有效地激活方面发挥着重要作用，并表明细菌是比以前认为的更复杂的生物体。
