Lopez Daniel, Koch Gudrun
Research Centre for Infectious Diseases (ZINF), University of Würzburg, Würzburg 97080, Germany; Institute for Molecular Infection Biology (IMIB), University of Würzburg, Würzburg 97080, Germany; Spanish National Centre for Biotechnology (CNB), Madrid 28049, Spain.
Research Centre for Infectious Diseases (ZINF), University of Würzburg, Würzburg 97080, Germany; Institute for Molecular Infection Biology (IMIB), University of Würzburg, Würzburg 97080, Germany.
Curr Opin Microbiol. 2017 Apr;36:76-84. doi: 10.1016/j.mib.2017.02.001. Epub 2017 Feb 23.
Recent studies show that internal organization of bacterial cells is more complex than previously appreciated. A clear example of this is the assembly of the nanoscale membrane platforms termed functional membrane microdomains. The lipid composition of these regions differs from that of the surrounding membrane; these domains confine a set of proteins involved in specific cellular processes such as protease secretion and signal transduction. It is currently thought that functional membrane microdomains act as oligomerization platforms and promote efficient oligomerization of interacting protein partners in bacterial membranes. In this review, we highlight the most noteworthy achievements, challenges and controversies of this emerging research field over the past five years.
最近的研究表明，细菌细胞的内部组织比之前认为的更为复杂。一个明显的例子是被称为功能性膜微区的纳米级膜平台的组装。这些区域的脂质组成与周围膜的脂质组成不同；这些微区限制了一组参与特定细胞过程（如蛋白酶分泌和信号转导）的蛋白质。目前认为，功能性膜微区充当寡聚化平台，并促进细菌膜中相互作用的蛋白质伙伴的高效寡聚化。在这篇综述中，我们重点介绍了过去五年中这个新兴研究领域最值得注意的成就、挑战和争议。
