Lin Kai, Meng Leng, Collins Jeremy D, Chowdhary Varun, Markl Michael, Carr James C
Department of Radiology, Northwestern University, 737 N Michigan Avenue, Suite 1600, Chicago, IL 60611.
Department of Radiology, Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Magn Reson Imaging. 2017 Jan;35:148-153. doi: 10.1016/j.mri.2016.08.009. Epub 2016 Aug 26.
To test the hypothesis that two-dimensional (2D) displacement encoding via stimulated echoes (DENSE) is a reproducible technique for the depiction of segmental myocardial motion in human subjects.
Following the approval of the institutional review board (IRB), 17 healthy volunteers without documented history of cardiovascular disease were recruited. For each participant, 2D DENSE were performed twice (at different days) and the images were obtained at basal, midventricular and apical levels of the left ventricle (LV) with a short-axis view. The radial thickening strain (Err), circumferential strain (Ecc), twist and torsion were calculated. The intra-, inter-observer and inter-study variations of DENSE-derived myocardial motion indices were evaluated using coefficient of variation (CoV) and intra-class correlation coefficient (ICC).
In total, there are 272 pairs of myocardial segments (data points) for comparison. There is good intra- and inter-observer reproducibility for all DENSE-derived measures in 17 participants. There is good inter-study reproducibility for peak Ecc (CoV=19.64%, ICC=0.8896, p<0.001), twist (CoV=33.11%, ICC=0.9135, p<0.001) and torsion (CoV=13.96%, ICC=0.8684, p<0.001). There is moderate inter-study reproducibility for Err (CoV=38.89%, ICC=0.7022, p<0.001).
DENSE is a reproducible technique for characterizing LV regional systolic myocardial motion on a per-segment basis in healthy volunteers.
验证二维（2D）激发回波位移编码（DENSE）技术在描绘人体节段性心肌运动方面是否具有可重复性。
经机构审查委员会（IRB）批准，招募了17名无心血管疾病病史记录的健康志愿者。对每位参与者进行两次二维DENSE检查（在不同日期），并通过短轴视图在左心室（LV）的基底、心室中部和心尖水平获取图像。计算径向增厚应变（Err）、圆周应变（Ecc）、扭转和扭矩。使用变异系数（CoV）和组内相关系数（ICC）评估DENSE衍生的心肌运动指标的观察者内、观察者间和研究间变异。
总共272对心肌节段（数据点）用于比较。17名参与者中所有DENSE衍生测量的观察者内和观察者间再现性良好。Ecc峰值（CoV = 19.64%，ICC = 0.8896，p < 0.001）、扭转（CoV = 33.11%，ICC = 0.9135，p < 0.001）和扭矩（CoV = 13.96%，ICC = 0.8684，p < 0.001）的研究间再现性良好。Err的研究间再现性中等（CoV = 38.89%，ICC = 0.7022，p < 0.001）。
DENSE是一种在健康志愿者中按节段表征左心室局部收缩期心肌运动的可重复技术。
