Liu Zhan-Qiu, Maforo Nyasha G, Renella Pierangelo, Halnon Nancy, Wu Holden H, Ennis Daniel B
Department of Radiology, Stanford University, Palo Alto, CA, USA.
Department of Radiological Sciences, University of California, Los Angeles, CA, USA.
Funct Imaging Model Heart. 2021 Jun;12738:232-241. doi: 10.1007/978-3-030-78710-3_23. Epub 2021 Jun 18.
Cardiomyopathy is the leading cause of mortality in boys with Duchenne muscular dystrophy (DMD). Left ventricular (LV) peak mid-wall circumferential strain (E) is a sensitive early biomarker for evaluating both the subtle and variable onset and the progression of cardiomyopathy in pediatric subjects with DMD. Cine Displacement Encoding with Stimulated Echoes (DENSE) has proven sensitive to changes in E, but its reproducibility has not been reported in a pediatric cohort or a DMD cohort. The was to quantify the intra-observer repeatability, and intra-exam and inter-observer reproducibility of global and regional E derived from cine DENSE in DMD patients (N = 10) and age-and sex-matched controls (N = 10). Global and regional E measures were considered reproducible in the intra-exam, intra-observer, and inter-observer comparisons. Intra-observer repeatability was highest, followed by intra-exam reproducibility and then inter-observer reproducibility. The smallest detectable change in E was 0.01 for the intra-observer comparison, which is below the previously reported yearly decrease of 0.013 ± 0.015 in E in DMD patients.
心肌病是杜氏肌营养不良症（DMD）男孩死亡的主要原因。左心室（LV）峰值中层圆周应变（E）是评估DMD儿科患者心肌病细微和可变发作以及进展的敏感早期生物标志物。刺激回波电影位移编码（DENSE）已被证明对E的变化敏感，但其在儿科队列或DMD队列中的可重复性尚未见报道。本研究旨在量化DMD患者（N = 10）和年龄及性别匹配的对照组（N = 10）中，通过电影DENSE得出的整体和局部E的观察者内重复性、检查内及观察者间的可重复性。在检查内、观察者内和观察者间比较中，整体和局部E测量值被认为具有可重复性。观察者内重复性最高，其次是检查内可重复性，然后是观察者间可重复性。观察者内比较中E的最小可检测变化为0.01，低于先前报道的DMD患者E每年0.013±0.015的下降幅度。
