Lee Sun Hee, Park Wan Beom, Lee Shinwon, Park Sohee, Kim Shin Woo, Lee Jong-Myung, Chang Hyun Ha, Kwon Ki Tae, Choe Pyoeng Gyun, Kim Nam Joong, Kim Hong Bin, Oh Myoung-Don
Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Antimicrob Agents Chemother. 2016 Oct 21;60(11):6928-6932. doi: 10.1128/AAC.01517-16. Print 2016 Nov.
Some proportion of type A blaZ gene-positive methicillin-susceptible Staphylococcus aureus strains exhibit the cefazolin inoculum effect (CIE). The type A blaZ gene was divided into two groups by single nucleotide polymorphisms (SNPs) at Ser226Pro and Cys229Tyr. The median cefazolin MICs at a high inoculum concentration were 5.69 μg/ml for the Ser-Cys group and 40.32 μg/ml for the Pro-Tyr group (P = 0.01). The SNPs at codons 226 and 229 in the amino acid sequence encoded by the blaZ gene were closely associated with the CIE.
部分携带A类blaZ基因的甲氧西林敏感金黄色葡萄球菌菌株表现出头孢唑林接种物效应(CIE)。根据Ser226Pro和Cys229Tyr处的单核苷酸多态性(SNP),A类blaZ基因被分为两组。高接种物浓度下,Ser-Cys组头孢唑林的最低抑菌浓度(MIC)中位数为5.69μg/ml,Pro-Tyr组为40.32μg/ml(P = 0.01)。blaZ基因编码的氨基酸序列中第226和229位密码子的SNP与CIE密切相关。