一头奶牛（Bos taurus）发生疫苗诱导的狂犬病病例：脑组织中疫苗株的分子特征分析
Vaccine-induced rabies case in a cow (Bos taurus): Molecular characterisation of vaccine strain in brain tissue.
作者信息
Vuta Vlad, Picard-Meyer Evelyne, Robardet Emmanuelle, Barboi Gheorghe, Motiu Razvan, Barbuceanu Florica, Vlagioiu Constantin, Cliquet Florence
机构信息
Institute for Diagnosis and Animal Health, Bucharest, Romania; University of Agronomic Study and Veterinary Medicine, Faculty of Veterinary Medicine, Bucharest, Romania.
Nancy OIE/WHO/EU Laboratory for Rabies and Wildlife, French Agency for Food, Environmental and Occupational Health & Safety, Malzéville, France.
出版信息
Vaccine. 2016 Sep 22;34(41):5021-5025. doi: 10.1016/j.vaccine.2016.08.013. Epub 2016 Aug 27.
Rabies is a fatal neuropathogenic zoonosis caused by the rabies virus of the Lyssavirus genus, Rhabdoviridae family. The oral vaccination of foxes - the main reservoir of rabies in Europe - using a live attenuated rabies virus vaccine was successfully conducted in many Western European countries. In July 2015, a rabies vaccine strain was isolated from the brain tissues of a clinically suspect cow (Bos taurus) in Romania. The nucleotide analysis of both N and G gene sequences showed 100% identity between the rabid animal, the GenBank reference SAD B19 strain and five rabies vaccine batches used for the national oral vaccination campaign targeting foxes.
狂犬病是一种由弹状病毒科狂犬病毒属的狂犬病病毒引起的致命性神经病原性人畜共患病。在许多西欧国家，已成功对狐狸（欧洲狂犬病的主要宿主）使用减毒活狂犬病病毒疫苗进行口服接种。2015年7月，从罗马尼亚一头临床疑似奶牛（Bos taurus）的脑组织中分离出一株狂犬病疫苗株。对N和G基因序列的核苷酸分析表明，该患病动物、GenBank参考SAD B19株以及用于针对狐狸的国家口服疫苗接种运动的五批狂犬病疫苗之间具有100%的同一性。
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