Ceva Innovation Center GmbH, Am Pharmapark, 06861, Dessau-Rosslau, Germany.
Virology Unit, Finnish Food Authority, Mustialankatu 3, 00790, Helsinki, Finland.
Acta Vet Scand. 2021 Oct 13;63(1):40. doi: 10.1186/s13028-021-00605-y.
To prevent re-emergence of wildlife-mediated rabies in Finland, oral rabies vaccine baits are distributed every year during autumn in southern Finland in a vaccination zone bordering Russia. Recently, Finland introduced a 3rd generation oral rabies virus vaccine bait. By analysing bait uptake and seroconversion in red foxes and raccoon dogs, the field efficacy of this new vaccine strain, SPBN GASGAS, was compared with the originally used highly efficacious 1st generation vaccine SAD B19.
Overall, 74.6% and 53.9% of the animals submitted from the vaccination area after the campaigns (2017-2019) tested positive for the presence of the bait marker and anti-rabiesvirus antibodies, respectively. No significant difference was observed between years, species and vaccine.
The field performance of the highly attenuated 3rd generation oral rabies vaccine, SPBN GASGAS, in terms of bait uptake and seroconversion was similar to the 1st generation vaccine, SAD B19, and therefore offers a suitable alternative.
为防止芬兰境内野生动物传播狂犬病的再次发生，每年秋季都会在与俄罗斯接壤的南部芬兰免疫区内投放口服狂犬病疫苗诱饵。最近，芬兰引入了第三代口服狂犬病病毒疫苗诱饵。通过分析红狐和浣熊犬对诱饵的摄取和血清转化情况，比较了这种新疫苗株 SPBN GASGAS 的现场效果与最初使用的高效 1 代疫苗 SAD B19。
在活动（2017-2019 年）后的免疫区内提交的动物中，总体上有 74.6%和 53.9%的动物检测到诱饵标记和抗狂犬病病毒抗体呈阳性。各年、物种和疫苗之间无显著差异。
在诱饵摄取和血清转化率方面，高度减毒的第三代口服狂犬病疫苗 SPBN GASGAS 的现场性能与第一代疫苗 SAD B19 相似，因此是一种合适的替代品。
