Szepietowski Jacek C, Reszke Radomir
Curr Probl Dermatol. 2016;50:124-32. doi: 10.1159/000446055. Epub 2016 Aug 23.
Pruritus is a bothersome and prevalent symptom reported by patients suffering from both cutaneous and extracutaneous diseases. Psychogenic pruritus, also referred to as functional itch disorder, is a distinct clinical entity. According to the definition proposed by the French Psychodermatology Group (FPDG) in 2007, the disorder is characterized by pruritus which is the chief complaint and psychologic factors that contribute to eliciting, worsening, and sustaining the symptoms. Specific diagnostic criteria were proposed, including 3 compulsory and 7 optional, of which 3 have to be met in order to establish the diagnosis. Psychogenic pruritus may require cooperation between dermatologists, psychiatrists, and psychologists. Psychotherapy and psychopharmacotherapy are mainstays of managing the disease. However, publications regarding psychogenic itch management are uncommon. Initially, general measures have to be taken, including avoiding irritating factors, preventing skin dryness, and frequent application of emollients. As in pruritus of other causes, several drugs are used, with more emphasis on substances that influence central nervous system: H1-antihistamines (hydroxyzine, chlorpheniramine, cyproheptadine, diphenhydramine, promethazine), tricyclic antidepressants (doxepin), tetracyclic antidepressants (mirtazapine), selective serotonin reuptake inhibitors (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline), antipsychotic drugs (pimozide), anticonvulsants (topiramate), and benzodiazepines (alprazolam), preferably depending on the coexisting symptoms.
瘙痒是患有皮肤疾病和皮肤外疾病的患者报告的一种令人烦恼且普遍存在的症状。心理性瘙痒,也称为功能性瘙痒症,是一种独特的临床实体。根据法国心理皮肤病学小组(FPDG)2007年提出的定义,该疾病的特征是瘙痒为主要症状,以及心理因素导致症状的引发、加重和持续。提出了具体的诊断标准,包括3项强制性标准和7项可选标准,其中必须满足3项才能确立诊断。心理性瘙痒可能需要皮肤科医生、精神科医生和心理学家之间的合作。心理治疗和心理药物治疗是管理该疾病的主要方法。然而,关于心理性瘙痒管理的出版物并不常见。最初,必须采取一般措施,包括避免刺激因素、防止皮肤干燥以及频繁使用润肤剂。与其他原因引起的瘙痒一样,会使用几种药物,更侧重于影响中枢神经系统的物质:H1抗组胺药(羟嗪、氯苯那敏、赛庚啶、苯海拉明、异丙嗪)、三环类抗抑郁药(多塞平)、四环类抗抑郁药(米氮平)、选择性5-羟色胺再摄取抑制剂(西酞普兰、艾司西酞普兰、氟西汀、氟伏沙明、帕罗西汀、舍曲林)、抗精神病药物(匹莫齐特)、抗惊厥药物(托吡酯)和苯二氮䓬类药物(阿普唑仑),最好根据并存症状来选择。