PEG/KI 催化体系下苄基膦酸酯的可持续、高效合成。
A Sustainable and Efficient Synthesis of Benzyl Phosphonates Using PEG/KI Catalytic System.
机构信息
Department of Chemistry, Institute of Chemical Technology Mumbai, India.
Department of Chemistry, SIES College of Arts, Science and Commerce Mumbai, India.
出版信息
Front Chem. 2016 Aug 16;4:35. doi: 10.3389/fchem.2016.00035. eCollection 2016.
An efficient and expedient protocol for the synthesis of benzyl phosphonates using KI/K2CO3 as a catalytic system and PEG-400 as benign solvent has been developed. The reaction proceeds smoothly at room temperature achieving excellent selectivity and yield of the corresponding products. The combination of PEG-400, KI, and K2CO3 in this reaction avoids the need of volatile/toxic organic solvents and reactive alkali metals or metal nanoparticles/hydrides. We believe that this benign combination (PEG-400 and KI) could be used for other related organic transformations.
一种使用 KI/K2CO3 作为催化体系和 PEG-400 作为良性溶剂的高效、简便的苄基膦酸酯合成方法已经开发出来。该反应在室温下顺利进行，具有优异的选择性和相应产物的产率。PEG-400、KI 和 K2CO3 的组合在该反应中避免了使用挥发性/有毒有机溶剂和反应性碱金属或金属纳米粒子/氢化物的需要。我们相信，这种良性组合（PEG-400 和 KI）可用于其他相关的有机转化。
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