[Principles of the organization and functioning of the metabolon microcompartment].

The approaches to the elucidation of principles of metabolon functioning and the applicability of concepts of "protein-machine" and "conjugated ionic hydrogen bond systems" are discussed. The term "metabolon" refers to a supramolecular complex of sequential metabolic enzymes and structural elements of the cell. It has been assumed that the metabolon microcompartment consists of separate units joined together by channels, in which the active and, possibly, allosteric sites of enzymes become approximated.