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埃塞俄比亚西南部新诊断青光眼患者的中央角膜厚度:一项横断面研究。

Central corneal thickness in newly diagnosed glaucoma patients in South West Ethiopia: a cross-sectional study.

作者信息

Tolesa Kumale, Gessesse Girum W

机构信息

Jimma University, Ethiopia, P.O. Box: 378, Jimma, Ethiopia.

出版信息

BMC Ophthalmol. 2016 Aug 31;16(1):152. doi: 10.1186/s12886-016-0334-x.

Abstract

BACKGROUND

Reports of central corneal thickness (CCT) among glaucoma patients, particularly for pseudoexfoliative glaucoma (PXG) and Primary Angle Closure Glaucoma (PACG) are scarce in the Sub-Saharan African (SSA) population. The aim of this study is to evaluate CCT in black patients with newly diagnosed glaucoma and ocular hypertension (OHT) in South West Ethiopia.

METHODS

This was a prospective study undertaken with an ultrasonic pachymeter from June 2014 to February 2015 in Jimma University Specialized Hospital. Patients aged 18 years and older newly diagnosed with glaucoma or OHT were included.

RESULTS

A total of 162 eyes of 162 subjects were included. Hundred and fifty five subjects were glaucomatous: (67 PXG, 42 Primary Open Angle Glaucoma (POAG), 28 PACG, 14 Normal Tension Glaucoma (NTG), 5 Juvenile Open Angle Glaucoma (JOAG) and 6 (OHT). The mean age was 59.3 ± 12.8 years. For the whole sample, CCT was 518.67 (±39.97) μm. OHT group had significantly greater CCT (576.33 ± 49.32 μm) than the glaucomatous groups (p = 0.004). POAG (506.69 ± 35.08 μm) and NTG (510.79 ± 44.37 μm) groups had thinner CCT than PXG (520.48 ± 38.95 μm), PACG (524.00 ± 37.16 μm), and JOAG (518.00 ± 30.82 μm) groups, but this was not statistically significant (p = 0. 296). There was a statistically significant decline of CCT with advanced age (P = 0.02). There wasn't significant difference of average CCT between the ethnic groups (P = 0.3) and gender (P = 0.064).

CONCLUSION

The mean CCT of Ethiopian glaucoma patients is thinner than Caucasians and similar to those reported from previous studies in Sub Saharan Africa. OHT patients had thicker CCT; there was no statistically significant difference observed in average CCT amongst glaucoma subtypes.

摘要

背景

在撒哈拉以南非洲(SSA)人群中,青光眼患者,尤其是剥脱性青光眼(PXG)和原发性闭角型青光眼(PACG)的中央角膜厚度(CCT)报告很少。本研究的目的是评估埃塞俄比亚西南部新诊断的青光眼和高眼压症(OHT)黑人患者的CCT。

方法

这是一项于2014年6月至2015年2月在吉姆马大学专科医院使用超声角膜测厚仪进行的前瞻性研究。纳入年龄在18岁及以上新诊断为青光眼或OHT的患者。

结果

共纳入162名受试者的162只眼睛。155名受试者患有青光眼:(67例PXG,42例原发性开角型青光眼(POAG),28例PACG,14例正常眼压性青光眼(NTG),5例青少年开角型青光眼(JOAG)和6例(OHT)。平均年龄为59.3±12.8岁。对于整个样本,CCT为518.67(±39.97)μm。OHT组的CCT(576.33±49.32μm)明显高于青光眼组(p = 0.004)。POAG(506.69±35.08μm)和NTG(510.79±44.37μm)组的CCT比PXG(520.48±38.95μm)、PACG(524.00±37.16μm)和JOAG(518.00±30.82μm)组薄,但差异无统计学意义(p = 0.296)。CCT随年龄增长有统计学意义的下降(P = 0.02)。不同种族(P = 0.3)和性别(P = 0.064)之间的平均CCT无显著差异。

结论

埃塞俄比亚青光眼患者的平均CCT比白种人薄,与撒哈拉以南非洲先前研究报告的结果相似。OHT患者的CCT较厚;青光眼各亚型之间的平均CCT无统计学显著差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8438/5007694/af6333019730/12886_2016_334_Fig1_HTML.jpg

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