Napoli J L, McCormick A M, Schnoes H K, DeLuca H F
Proc Natl Acad Sci U S A. 1978 Jun;75(6):2603-5. doi: 10.1073/pnas.75.6.2603.
A retinoid was isolated by a multistep procedure from the small intestines of vitamin A-deficient rats given a single dose of retinoic acid. The compound, designated 8II, was pure, as demonstrated by four high-pressure liquid chromatographic procedures. It was positively identified as 5,8-oxyretinoic acid by ultraviolet spectrophotometry, mass spectrometry, and spectral and chromatographic comparison to known compounds. It is probable that 5,8-oxyretinoic acid was produced from 5,6-epoxyretinoic acid under the acidic conditions used in the isolation. It is highly probable, therefore, that the natural product is 5,6-epoxyretinoic acid.
通过多步程序从给予单剂量视黄酸的维生素A缺乏大鼠的小肠中分离出一种类视黄醇。该化合物命名为8II，经四种高压液相色谱程序证明是纯的。通过紫外分光光度法、质谱法以及与已知化合物的光谱和色谱比较，确定其为5,8-氧代视黄酸。在分离所用的酸性条件下，5,8-氧代视黄酸可能由5,6-环氧视黄酸产生。因此，很可能天然产物是5,6-环氧视黄酸。
