McCormick A M, Napoli J L, Yoshizawa S, DeLuca H F
Biochem J. 1980 Feb 15;186(2):475-81. doi: 10.1042/bj1860475.
5,6-Epoxyretinoic acid was detected in small intestine, kidney, liver, testes and serum of vitamin A-deficient rats 3 h after a single physiological dose of [3H]retinoic acid. The maximum concentration of 5,6-epoxide in intestinal mucosa was observed 3 h after intrajugular administration of retinoic acid. However, at 7 h post administration, no 5,6-epoxyretinoic acid was detected in mucosa, demonstrating the rapid intestinal metabolism or excretion of this metabolite. No 5,6-epoxy[3H]retinoic acid was detected in mucosa, liver or serum of retinoic acid-repleted rats 3 h after administration of 2 micrograms of [3H]retinoic acid.
在给维生素A缺乏的大鼠单次生理剂量的[3H]视黄酸3小时后，在其小肠、肾脏、肝脏、睾丸和血清中检测到了5,6-环氧视黄酸。颈静脉注射视黄酸后3小时，在肠黏膜中观察到5,6-环氧化物的最大浓度。然而，给药后7小时，在黏膜中未检测到5,6-环氧视黄酸，这表明该代谢产物在肠道中快速代谢或排泄。给维生素A充足的大鼠注射2微克[3H]视黄酸3小时后，在其黏膜、肝脏或血清中未检测到5,6-环氧[3H]视黄酸。
