Maranda Eric L, Akintilo Lisa, Hundley Kelsey, Nguyen Austin H, Moore Kevin J, Zullo Joseph, Jimenez Joaquin J
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1475 NW 12th Ave., Miami, FL, 33136, USA.
Feinberg School of Medicine at Northwestern University, Chicago, IL, USA.
Lasers Med Sci. 2017 Jan;32(1):243-248. doi: 10.1007/s10103-016-2065-x. Epub 2016 Sep 2.
Pearly penile papules (PPP) present as dome-shaped papules of no more than 3 mm in diameter that line the base of the glans of the penis. These benign lesions affect between 14.3 and 48 % of men. While often asymptomatic, PPP can cause a great deal of psychological distress that may warrant treatment. Current treatment options include cryotherapy, electrodessication, and curettage (ED&C). However, these modalities may have considerable adverse cosmetic effects, including scarring, pain, and pigmentary changes. Laser modalities offer clear potential for improved cosmetic outcome in PPP treatment, but is not routinely used. Thus, a systematic review of available literature using the National Library of Medicine database PubMed was completed to find articles relevant to the treatment of PPP with laser and light therapy. The systematic search and screening of articles resulted in inclusion of eight articles discussing a total of 55 patients with PPP treated by laser therapy. The present systematic review found that erbium:yttrium-aluminum-garnet (Er:YAG) and CO laser were the most commonly reported (n = 45 and 7, respectively). Furthermore, the use of CO, Er:YAG, pulsed dye laser, and fractional photothermolysis therapies demonstrated complete clearance of PPP in all cases with minimal complications and discomfort. Thus, based on the currently available evidence, laser therapy is a well-tolerated and efficacious method for treating PPP with minimal long-term adverse effects and a cosmetically desirable outcome. Although the included studies are limited in power, this systematic review offers clinically relevant insight into the potential for laser therapy.
珍珠状阴茎丘疹（PPP）表现为直径不超过3毫米的圆顶状丘疹，排列在阴茎龟头基部。这些良性病变影响14.3%至48%的男性。虽然通常无症状，但PPP可导致大量心理困扰，可能需要治疗。目前的治疗选择包括冷冻疗法、电干燥法和刮除术（ED&C）。然而，这些方法可能会产生相当大的不良美容效果，包括瘢痕形成、疼痛和色素沉着变化。激光疗法在PPP治疗中具有改善美容效果的明显潜力，但未被常规使用。因此，利用美国国立医学图书馆数据库PubMed对现有文献进行了系统综述，以查找与激光和光疗治疗PPP相关的文章。对文章的系统检索和筛选共纳入了8篇讨论55例接受激光治疗的PPP患者的文章。本系统综述发现，铒：钇铝石榴石（Er:YAG）激光和CO2激光是最常被报道的（分别为n = 45和7）。此外，使用CO2、Er:YAG、脉冲染料激光和分次光热解疗法在所有病例中均显示PPP完全清除，并发症和不适最小。因此，根据目前可得的证据，激光疗法是一种耐受性良好且有效的治疗PPP的方法，长期不良反应最小，美容效果理想。尽管纳入的研究样本量有限，但本系统综述为激光疗法的潜力提供了临床相关见解。
