从三叶芫花中提取的高含氧三藜芦烷型柠檬苦素。

Highly oxygenous trichilin-type limonoids from Trichilia sinensis.

机构信息

Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.

出版信息

Chin J Nat Med. 2019 Dec;17(12):912-917. doi: 10.1016/S1875-5364(19)30112-8.

DOI:10.1016/S1875-5364(19)30112-8

PMID:31882045

Abstract

Six new trichilin-type limonoids (1-6) with C-19/29 lactol or acetal bridge and a new ring intact limonoid (7) were isolated from the desiccative ripe fruits of Trichilia sinensis. Their structures were determined by extensive spectroscopic methods including H NMR, C NMR, HSQC, HMBC, ROESY experiments as well as HRESI-MS data. All isolated compounds were evaluated for toxicities against human pulmonary carcinoma A549 and Hela cell lines by sulforhodamine B (SRB) method. Compound 7 showed weak inhibitory activity in Hela cell line at 40 μmol·L.

摘要

从干燥成熟的三叶芫花果实中分离得到了 6 个新的三藜林型柠檬苦素（1-6），它们具有 C-19/29 内酯或缩醛桥和一个新的完整的环柠檬苦素（7）。通过广泛的光谱方法，包括 1H NMR、13C NMR、HSQC、HMBC、ROESY 实验以及 HRESI-MS 数据，确定了它们的结构。采用磺基罗丹明 B（SRB）法评价了所有分离得到的化合物对人肺癌 A549 和 Hela 细胞系的毒性。化合物 7 在 40 μmol·L 时对 Hela 细胞系表现出较弱的抑制活性。