从三叶芫花根中提取的柠檬苦素及其细胞毒性。

Limonoids from the roots of Trichilia sinensis and their cytotoxicities.

机构信息

Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, People's Republic of China.

Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou, 571737, People's Republic of China.

出版信息

Arch Pharm Res. 2018 Dec;41(12):1170-1177. doi: 10.1007/s12272-017-0915-0. Epub 2017 Nov 23.

DOI:10.1007/s12272-017-0915-0

PMID:29170993

Abstract

Six new compounds (1-4, 8, 10), along with six known limonoids (5-7, 9, 11, 12), were isolated from the roots of Trichilia sinensis. Their structures were elucidated on the basis of extensive spectroscopic methods including H NMR, C NMR, DEPT, HSQC, HMBC, H-H COSY and ROESY experiments, as well as by comparison with the literature. All the compounds were evaluated for cytotoxicities against K562, SGC-7901 and BEL-7402 cell lines. Compounds 2, 7, 10, 11, and 12 showed weak inhibitory activity to the selected cell lines.

摘要

从三叶芫花的根部分离得到了 6 个新化合物（1-4、8、10）和 6 个已知的柠檬苦素（5-7、9、11、12）。根据广泛的光谱方法，包括 H NMR、C NMR、DEPT、HSQC、HMBC、H-H COSY 和 ROESY 实验，以及与文献的比较，确定了它们的结构。所有化合物均对 K562、SGC-7901 和 BEL-7402 细胞系的细胞毒性进行了评价。化合物 2、7、10、11 和 12 对所选细胞系表现出较弱的抑制活性。