Schuster Randi Melissa, Hanly Ailish, Gilman Jodi, Budney Alan, Vandrey Ryan, Evins A Eden
Center for Addiction Medicine, Department of Psychiatry, Massachusetts General Hospital (MGH) Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Center for Addiction Medicine, Department of Psychiatry, Massachusetts General Hospital (MGH) Boston, MA, USA.
Drug Alcohol Depend. 2016 Oct 1;167:199-206. doi: 10.1016/j.drugalcdep.2016.08.622. Epub 2016 Aug 28.
Rates of young adult cannabis use are rising, perceived harm is at its historical nadir, and most users do not want to quit. Most studies evaluating effects of cannabis use in young adults are cross-sectional, limiting causal inference. A method to reliably induce abstinence periods in cannabis users would allow assessment of the effects of abstinence and resumption of use on a variety of outcomes in a within-subjects, repeated measures design.
We examined the efficacy and feasibility of a voucher-based contingency management procedure for incentivizing one month of continuous cannabis abstinence among young adults who reported at least weekly cannabis use, volunteered to participate in a laboratory study, and did not express a desire to discontinue cannabis use long-term. Continuous cannabis abstinence was reinforced with an escalating incentive schedule, and self-report of abstinence was confirmed by frequent quantitative assays of urine cannabis metabolite (THCCOOH) concentration. New cannabis use during the abstinence period was determined using an established algorithm of change in creatinine-adjusted cannabis metabolite concentrations between study visits.
Thirty-eight young adults, aged 18-25 years, enrolled and 34 (89.5%) attained biochemically confirmed 30-day abstinence. Among those who attained abstinence, 93.9% resumed regular use within two-weeks of incentive discontinuation.
Findings support the feasibility and efficacy of contingency management to elicit short-term, continuous cannabis abstinence among young adult, non-treatment seeking, regular cannabis users. Further work should test the effectiveness of this contingency management procedure for cannabis abstinence in periods longer than one month, which may be required to evaluate some effects of abstinence.
年轻成年人使用大麻的比例正在上升,对其危害的认知处于历史最低点,且大多数使用者并不想戒掉。大多数评估年轻成年人使用大麻影响的研究都是横断面研究,限制了因果推断。一种能可靠诱导大麻使用者戒断期的方法,将允许在受试者内重复测量设计中评估戒断及恢复使用对各种结果的影响。
我们研究了基于代金券的应急管理程序在激励至少每周使用一次大麻、自愿参与实验室研究且未表示有长期停用大麻意愿的年轻成年人连续一个月戒除大麻方面的有效性和可行性。通过逐步增加的激励计划强化连续戒除大麻的行为,通过对尿液中大麻代谢物(四氢大麻酚羧酸,THCCOOH)浓度进行频繁定量检测来确认戒断的自我报告。使用既定的研究访视间肌酐校正大麻代谢物浓度变化算法来确定戒断期内新的大麻使用情况。
38名年龄在18 - 25岁的年轻成年人参与研究,34人(89.5%)实现了经生化确认的30天戒断。在实现戒断的人群中,93.9%在激励措施停止后的两周内恢复了常规使用。
研究结果支持应急管理在促使年轻的、未寻求治疗的常规大麻使用者短期持续戒除大麻方面的可行性和有效性。进一步的工作应测试这种应急管理程序在超过一个月的时间段内实现大麻戒断的有效性,这可能是评估某些戒断效果所必需的。