College of Food Science and Nutritional Engineering, National Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture; Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education, China Agricultural University, Beijing 100083, China.
College of Food Science and Nutritional Engineering, National Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture; Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education, China Agricultural University, Beijing 100083, China.
Biotechnol Adv. 2016 Nov 15;34(7):1210-1224. doi: 10.1016/j.biotechadv.2016.08.003. Epub 2016 Aug 31.
The interplay between the host and host-associated gut microbiota is an area of increasing interest during the recent decade. From young infants to elderly people, from primitive tribes to modern societies, accumulating evidence has suggested the association of critical physiological roles of gut microbiota in the pathogenesis of a variety of human metabolic, immunological and neurological diseases. Importantly, it appears that the relationship between the gut microbiota and disease is bidirectional, instead of causal or consequential. Personalized nutritional and therapeutic strategies targeting the gut microbiota such as prebiotics, probiotics, drugs and fecal microbiota transplantation may create a new era in the human health.
近年来,宿主与宿主相关的肠道微生物群之间的相互作用是一个日益受到关注的领域。从婴幼儿到老年人,从原始部落到现代社会,越来越多的证据表明,肠道微生物群在多种人类代谢、免疫和神经疾病的发病机制中具有关键的生理作用。重要的是,肠道微生物群与疾病之间的关系似乎是双向的,而不是因果关系或后果关系。针对肠道微生物群的个性化营养和治疗策略,如益生元、益生菌、药物和粪便微生物群移植,可能会开创人类健康的新时代。