Bounihi Abdenour, Bitam Arezki, Bouazza Asma, Yargui Lyece, Koceir Elhadj Ahmed
a Department of Biology and Physiology of Organisms, Bioenergetics and Intermediary Metabolism Team , FSB, University of Sciences and Technology Houari Boumediene (USTHB) , Algiers , Algeria.
b Department of Food Technology and Human Nutrition , Ecole Nationale Supérieure Agronomique , El Harrach , Algiers , Algeria.
Pharm Biol. 2017 Dec;55(1):43-52. doi: 10.1080/13880209.2016.1226369. Epub 2016 Sep 5.
Fruit vinegars (FVs) are used in Mediterranean folk medicine for their hypolipidemic and weight-reducing properties.
To investigate the preventive effects of three types of FV, commonly available in Algeria, namely prickly pear [Opuntia ficus-indica (L.) Mill (Cectaceae)], pomegranate [Punica granatum L. (Punicaceae)], and apple [Malus domestica Borkh. (Rosaceae)], against obesity-induced cardiomyopathy and its underlying mechanisms.
Seventy-two male Wistar rats were equally divided into 12 groups. The first group served as normal control (distilled water, 7 mL/kg bw), and the remaining groups were respectively treated with distilled water (7 mL/kg bw), acetic acid (0.5% w/v, 7 mL/kg bw) and vinegars of pomegranate, apple or prickly pear (at doses of 3.5, 7 and 14 mL/kg bw, acetic acid content as mentioned above) along with a high-fat diet (HFD). The effects of the oral administration of FV for 18 weeks on the body and visceral adipose tissue (VAT) weights, plasma inflammatory and cardiac enzymes biomarkers, and in heart tissue were evaluated.
Vinegars treatments significantly (p < .05) attenuated the HFD-induced increase in bw (0.2-0.5-fold) and VAT mass (0.7-1.8-fold), as well as increase in plasma levels of CRP (0.1-0.3-fold), fibrinogen (0.2-0.3-fold), leptin (1.7-3.7-fold), TNF-α (0.1-0.6-fold), AST (0.9-1.4-fold), CK-MB (0.3-1.4-fold) and LDH (2.7-6.7-fold). Moreover, vinegar treatments preserved myocardial architecture and attenuated cardiac fibrosis.
These findings suggest that pomegranate, apple and prickly pear vinegars may prevent HFD-induced obesity and obesity-related cardiac complications, and that this prevention may result from the potent anti-inflammatory and anti-adiposity properties of these vinegars.
果醋（FVs）在地中海民间医学中因其降血脂和减肥特性而被使用。
研究阿尔及利亚常见的三种果醋，即仙人掌果[仙人掌（仙人掌科）]、石榴[石榴（石榴科）]和苹果[苹果（蔷薇科）]对肥胖诱导的心肌病及其潜在机制的预防作用。
72只雄性Wistar大鼠平均分为12组。第一组作为正常对照组（蒸馏水，7 mL/kg体重），其余各组分别用蒸馏水（7 mL/kg体重）、醋酸（0.5% w/v，7 mL/kg体重）以及石榴、苹果或仙人掌果醋（剂量分别为3.5、7和14 mL/kg体重，醋酸含量如上所述）与高脂饮食（HFD）一起处理。评估口服果醋18周对体重、内脏脂肪组织（VAT）重量、血浆炎症和心脏酶生物标志物以及心脏组织的影响。
果醋处理显著（p < 0.05）减轻了高脂饮食诱导的体重增加（0.2 - 0.5倍）和内脏脂肪组织质量增加（0.7 - 1.8倍），以及血浆中CRP（0.1 - 0.3倍）、纤维蛋白原（0.2 - 0.3倍）、瘦素（1.7 - 3.7倍）、TNF-α（0.1 - 0.6倍）、AST（0.9 - 1.4倍）、CK-MB（0.3 - 1.4倍）和LDH（2.7 - 6.7倍）水平的升高。此外，果醋处理保留了心肌结构并减轻了心脏纤维化。
这些发现表明，石榴、苹果和仙人掌果醋可能预防高脂饮食诱导的肥胖和肥胖相关的心脏并发症，并且这种预防可能源于这些果醋强大的抗炎和抗肥胖特性。
