Mujagić H, Krnjajić N, Jevrić A
Clinical Oncology Service, Clinical Hospital Center, Bosna, Yugoslavia.
J Cancer Res Clin Oncol. 1989;115(4):383-7. doi: 10.1007/BF00400967.
Tissue levels of prostaglandins PGE1, PGE2, PGF1 alpha and PGF2 alpha were determined in muscle tissues of pregnant, and in tumor tissue of pregnant tumor-bearing female syngeneic Balb/c mice bearing a transplanted methylcholanthrene-induced fibrosarcoma. Tests were done on the 7th, 10th, and 15th days of tumor growth/pregnancy using a thin-layer chromatography method. The results showed significantly increased levels of prostaglandins in tumor-bearing animals as well as in pregnant tumor-bearing hosts when compared to controls. Changes in the levels of PGE1 in pregnant mice were the most prominent among all prostaglandins tested. In these animals, the mutual relations between prostaglandin subclasses were not affected. In tumor-bearing mice, especially those which were pregnant, the inversion of prostaglandins of the E series was observed. Tumor changed the levels of the E series prostaglandins in favour of PGE2. However, it did not change the relation between those of the F series. The levels of PGE2 were more expressed in pregnant tumor-bearing hosts than in their non-pregnant counterparts. This has led us to the conclusion that, besides the malignant tumor, the pregnancy itself also potentiates immunosuppression. Blocking of PGE2 production in tumor-bearing animals might have potential therapeutic implications.
在怀孕的同基因Balb/c小鼠以及携带移植的甲基胆蒽诱导纤维肉瘤的怀孕荷瘤雌性同基因Balb/c小鼠的肿瘤组织中，测定了前列腺素PGE1、PGE2、PGF1α和PGF2α的组织水平。在肿瘤生长/怀孕的第7天、第10天和第15天，使用薄层色谱法进行检测。结果显示，与对照组相比，荷瘤动物以及怀孕荷瘤宿主中前列腺素水平显著升高。在所有检测的前列腺素中，怀孕小鼠中PGE1水平的变化最为显著。在这些动物中，前列腺素亚类之间的相互关系未受影响。在荷瘤小鼠中，尤其是怀孕的荷瘤小鼠，观察到E系列前列腺素的倒置。肿瘤改变了E系列前列腺素的水平，使其有利于PGE2。然而，它并未改变F系列前列腺素之间的关系。怀孕荷瘤宿主中PGE2的水平比未怀孕的对应宿主中表达得更高。这使我们得出结论，除了恶性肿瘤外，怀孕本身也会增强免疫抑制。在荷瘤动物中阻断PGE2的产生可能具有潜在的治疗意义。
