抗体形成：给予过量非特异性刺激物后反应降低。
Antibody formation: reduced responses after administration of excessive amounts of nonspecific stimulators.
作者信息
Braun W, Ishizuka M
出版信息
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1114-6. doi: 10.1073/pnas.68.6.1114.
Abstract
Enhancement of antibody formation in vitro and in vivo by poly(A.U), cyclic AMP, dibutyryl cyclic AMP, or any one of these agents in combination with theophylline or caffeine, is usually limited to certain dose ranges. High doses of these nonspecific stimulators can produce less or no enhancement, or may actually inhibit antibody formation. Such dose-response relationships may be pertinent to an understanding of phenomena of specific immunological nonresponsiveness and certain types of antigenic competition.
摘要
聚（A.U）、环磷酸腺苷（cAMP）、二丁酰环磷酸腺苷（dibutyryl cAMP）或这些物质中的任何一种与茶碱或咖啡因联合使用，在体外和体内增强抗体形成的作用通常局限于特定剂量范围。高剂量的这些非特异性刺激剂可能产生较少的增强作用或无增强作用，甚至可能实际抑制抗体形成。这种剂量反应关系可能与理解特异性免疫无反应现象和某些类型的抗原竞争有关。
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本文引用的文献
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Immunization of dissociated spleen cell cultures from normal mice.对来自正常小鼠的脾细胞解离培养物进行免疫接种。
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