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Zika 病毒在妊娠晚期致胎儿感染:2 例报告。

Fetal Infection by Zika Virus in the Third Trimester: Report of 2 Cases.

机构信息

Department of Radiology, Faculdade de Medicina de São José do Rio Preto (FAMERP).

Hospital da Criança e Maternidade.

出版信息

Clin Infect Dis. 2016 Dec 15;63(12):1622-1625. doi: 10.1093/cid/ciw613. Epub 2016 Sep 6.

DOI:10.1093/cid/ciw613
PMID:27601223
Abstract

Zika virus (ZIKV) infection acquired during pregnancy is associated with congenital microcephaly. We describe 2 cases of ZIKV infection in women in their 36th week of pregnancy whose fetuses had preserved head circumference at birth and findings of subependymal cysts and lenticulostriate vasculopathy in postnatal imaging. These represent the first signs of congenital brain injury acquired due to ZIKV in the third trimester.

摘要

寨卡病毒(ZIKV)感染在怀孕期间获得与先天性小头畸形有关。我们描述了 2 例在妊娠第 36 周的妇女感染寨卡病毒的病例,她们的胎儿在出生时头围正常,在产后影像学检查中发现室管膜下囊肿和纹状体血管病变。这些是寨卡病毒在妊娠晚期引起的先天性脑损伤的首例表现。

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Isogenic human trophectoderm cells demonstrate the role of and associated variants in ZIKV infection.
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