Agarwal Rashmi, Chaudhary Minal, Bohra Shruti, Bajaj Shree
Department of Oral and Maxillofacial Pathology, Dr. B. R. Ambedkar Institute of Dental Sciences and Hospital, Patna, Bihar, India.
Department of Oral and Maxillofacial Pathology and Microbiology, Sharad Pawar Dental College, Wardha, Maharashtra, India.
J Oral Maxillofac Pathol. 2016 May-Aug;20(2):173-7. doi: 10.4103/0973-029X.185933.
Natural killer (NK) cells are important effector lymphocytes. NK cells are considered to represent innate immune system. NK cells target and kill aberrant cells such as virally infected and tumorigenic cells. The purpose of this study was to assess the expression of CD57 in oral squamous cell carcinoma (OSCC) and to correlate the expression of CD57 with 3 years survival in patients with OSCC.
About 100 histopathologically diagnosed cases of OSCC of various grades were divided into two groups, i.e., Group I (dead patients) and Group II (live patients) from the archives of Department of Oral Pathology and Microbiology. CD57 was detected in these tissues by immunohistochemistry.
The results were analyzed using Spearman's correlation coefficient and students unpaired t-test. The mean CD57 labeling index in Group II was significantly higher than that found in Group I (P = 0.000). There was a significant correlation (P = 0.00) in the mean CD57 levels between Groups I and II and prognosis of patient.
CD57 could be a good prognostic marker for OSCC patients.
自然杀伤（NK）细胞是重要的效应淋巴细胞。NK细胞被认为代表先天性免疫系统。NK细胞靶向并杀死异常细胞，如病毒感染细胞和致瘤细胞。本研究的目的是评估CD57在口腔鳞状细胞癌（OSCC）中的表达，并将CD57的表达与OSCC患者的3年生存率相关联。
从口腔病理学和微生物学系的档案中选取约100例经组织病理学诊断的不同分级OSCC病例，分为两组，即I组（死亡患者）和II组（存活患者）。通过免疫组织化学检测这些组织中的CD57。
采用Spearman相关系数和学生非配对t检验分析结果。II组的平均CD57标记指数显著高于I组（P = 0.000）。I组和II组之间的平均CD57水平与患者预后存在显著相关性（P = 0.00）。
CD57可能是OSCC患者的一个良好预后标志物。
